Document Detail

Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: a literature review.
MedLine Citation:
PMID:  23372352     Owner:  NLM     Status:  MEDLINE    
Hepatoid adenocarcinoma (HAC) is a rare but important special type of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma (HCC), and prompt and correct diagnosis can be a challenge, especially in endemic areas with a high incidence of HCC. To date, HAC has only been reported in case series or single case reports, so we aimed to review the clinicopathological characteristics of HAC to obtain a more complete picture of this rare form of extrahepatic adenocarcinoma. All the articles about HAC published from 2001 to 2011 were reviewed, and clinicopathological findings were extracted for analysis. A late middle-aged male with high serum α-fetoprotein and atypical image finding of HCC should raise the suspicion of HAC, and characteristic pathological immunohistochemical stains can help with the differential diagnosis. Novel immunohistochemical markers may be useful to clearly differentiate HAC from HCC. Once metastatic HAC is diagnosed, the primary tumor origin should be identified for adequate treatment. The majority of HAC originates from the stomach, so panendoscopy should be arranged first.
Jiann-Sheng Su; Yu-Tso Chen; Ren-Ching Wang; Chun-Ying Wu; Shou-Wu Lee; Teng-Yu Lee
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  19     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2014-01-03     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  321-7     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / blood,  diagnosis*,  secondary*
Age Factors
Aged, 80 and over
Carcinoma, Hepatocellular / blood,  diagnosis*,  pathology*
Diagnosis, Differential
Liver Neoplasms / blood,  diagnosis*,  secondary*
Middle Aged
Sex Factors
Stomach Neoplasms / pathology
Tumor Markers, Biological / blood
alpha-Fetoproteins / metabolism
Reg. No./Substance:
0/Tumor Markers, Biological; 0/alpha-Fetoproteins

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