Document Detail

Clinicopathological and biological assessment of lung cancers with pleural dissemination.
MedLine Citation:
PMID:  10800788     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study provides the surgical outcome of lung cancer patients with pleural dissemination, with the assessment of the clinicopathological and biological prognostic factors. METHODS: Forty-three patients who underwent operations were studied. Vascular endothelial growth factor (VEGF) and autocrine motility factor receptor (AMFR/gp78) expression was immunohistochemically evaluated. RESULTS: In total, the overall 3 and 5-year survival rates were 31.4% and 13.1%, respectively. The patients who underwent the pleuropneumonectomy had a worse outcome than those who underwent limited operations (pleurectomy plus parenchymal resections were less than pneumonectomy). VEGF and AMFR/gp78 were highly expressed in primary tumors. Among the patients who underwent limited operations, pathological types other than adenocarcinoma and high expression of VEGF were significantly associated with a worse outcome. The pathological type was the only characteristic to retain a significant independent prognostic impact on overall survival. CONCLUSIONS: The results imply the validation of limited operation for lung cancer with pleural dissemination for the local control. High frequency of VEGF and AMFR/gp78 expression conform to the interpretation that patients with pleural dissemination have a high-risk of systemic disease.
Y Ohta; Y Tanaka; T Hara; M Oda; S Watanabe; J Shimizu; Y Watanabe
Related Documents :
18979138 - Expression and clinical significance of cell cycle regulatory proteins in gallbladder a...
17981018 - Integrin alphanvbeta6 acts as a prognostic indicator in gastric carcinoma.
9570628 - Prognostic significance of c-erbb-2 oncoprotein expression in intestinal-type adenocarc...
15499618 - Novel markers for poor prognosis in head and neck cancer.
21989448 - Primary renal angiosarcoma: case report and review of world literature.
12168928 - Adjuvant pelvic irradiation in patients with node-negative carcinoma of the uterine cer...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  69     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-19     Completed Date:  2000-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1025-9     Citation Subset:  AIM; IM    
First Department of Surgery, Kanazawa University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / pathology*
Autocrine Motility Factor / metabolism
Carcinoma, Squamous Cell / pathology*
Endothelial Growth Factors / metabolism
Lung Neoplasms / pathology*
Lymphokines / metabolism
Middle Aged
Pleura / pathology*
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Reg. No./Substance:
0/Autocrine Motility Factor; 0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Segmental nonanastomotic bronchial stenosis after lung transplantation.
Next Document:  Long-term safety and tolerance of silicone and self-expandable airway stents: an experimental study.