Document Detail


Clinicopathological aspects of mucosa-associated lymphoid tissue (MALT) lymphoma of the parotid gland: A retrospective single-center analysis of 28 cases.
MedLine Citation:
PMID:  20737498     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND.: In constrast to its gastric counterpart, mucosa-associated lymphoid tissue (MALT) lymphoma of the parotid gland has not been studied extensively. We analyzed the clinicopathological features and the clinical course of all patients with parotid gland MALT lymphoma diagnosed and treated at our institution. METHODS.: Patient characteristics including an underlying autoimmune disease, disease stage, genetic aberrations, treatment, and clinical course were assessed and evaluated. Twenty-eight patients (19 women, 9 men) were identified; median age at diagnosis was 49 years (interquartile range [IQR], 40-56), and 18 patients (64%) had an underlying autoimmune disease. Eleven had stage IE, 7 patients had stage IIE, and 10 had advanced disease (stage IV). RESULTS.: Genetic aberrations were detected in 9 of 20 patients; 5 patients had trisomy 3, 2 patients had a t(11;18)(q21;21) translocation, 1 had trisomy 3 and 18, and 1 patient had a t(14;18)(q32;q21) translocation plus trisomy 18. After a median follow-up time of 62 months (IQR, 32-98 months), 24 patients (86%) are alive. Fifteen patients are free from lymphoma, whereas 13 patients (46%) have had a relapse. CONCLUSION.: Our data suggest that MALT lymphoma of the parotid gland is often associated with autoimmune diseases and that trisomy 3 is the most common genetic feature of this disease. The high rate of relapse warrants further study on optimal therapy of such patients. © 2010 Wiley Periodicals, Inc. Head Neck, 2011.
Authors:
Marlene Troch; Michael Formanek; Berthold Streubel; Leonhard Müllauer; Andreas Chott; Markus Raderer
Related Documents :
15623708 - Etanercept treatment in corticosteroid-dependent myasthenia gravis.
25364358 - Pulmonary function tests in ulcerative colitis.
25346048 - Soluble cd163, a specific macrophage activation marker, is decreased by anti-tnf-α ant...
8482958 - Association of hla-bw46dr9 combination with juvenile myasthenia gravis in chinese.
22203408 - Comparison of stroke work between repaired tetralogy of fallot and normal right ventric...
23735858 - Does a patent foramen ovale influence cognitive function in dialysis patients?
Publication Detail:
Type:  Journal Article     Date:  2010-08-24
Journal Detail:
Title:  Head & neck     Volume:  33     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  763-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Affiliation:
Department of Internal Medicine I, Division of Oncology and Cancer Center, Medical University of Vienna, Vienna, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neck dissections in the United States from 2000 to 2006: volume, indications, and regionalization.
Next Document:  Classification of papillary thyroid microcarcinoma according to size and fine-needle aspiration cyto...