Document Detail


Clinicopathological analysis of primary epithelial appendiceal neoplasms.
MedLine Citation:
PMID:  19851895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Appendiceal carcinomas are classified into three distinct histopathological disease entities: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), or peritoneal mucinous carcinomatosis with intermediate or discorant features (PMCA I/D). The treatment of appendiceal tumors should be based on accurate histopathological classification, per previously reported case series. The objective of this study was to evaluate the clinicopathologic presentation and outcome of patients with appendiceal tumors treated at our institution over a 15-year period. We identified patients with appendiceal tumors diagnosed or treated at our institution from January 1989 through May 2004. Chart review for age, gender, signs and symptoms at diagnosis, and treatment was performed. Review of the pathologic specimens was performed and tumors were classified as DPAM, PMCA I/D, or PMCA. Forty patients were identified (median age 52.5 years; males 38%). The number of patients with DPAM, PMCA I/D, and PMCA was 15 (38%), 6 (15%), and 18 (46%), respectively. Peritoneal involvement was seen in 11 (73%) of patients with DPAM, 5 (83%) of PMCA I/D, and 11 (61%) of PMCA. The median survival for patients with DPAM, PMCA I/D, and PMCA was 7.7 years (90% CI: 2.9--upper limit not estimable), 1.2 years (90% CI: 0.9-1.6), and 0.7 years (90% CI: 0.4-1.5), respectively. The difference in survival across the three groups was statistically significant. Three distinct histopathological disease entities exist in appendiceal tumors. The prognosis and management of these tumors should be based on the extent of disease and pathologic diagnosis.
Authors:
Sachin Gupta; Venkata Parsa; Volkan Adsay; Lance K Heilbrun; Daryn Smith; Anthony F Shields; Donald Weaver; Philip A Philip; Bassel F El-Rayes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-10-23
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  27     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-04-08     Revised Date:  2014-01-16    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1073-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma, Mucinous / secondary*,  therapy
Adult
Aged
Appendiceal Neoplasms / pathology*,  therapy
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasm Staging
Neoplasms, Glandular and Epithelial / secondary*,  therapy
Peritoneal Neoplasms / secondary*,  therapy
Prognosis
Survival Rate
Grant Support
ID/Acronym/Agency:
CA-22453/CA/NCI NIH HHS; P30 CA022453/CA/NCI NIH HHS
Comments/Corrections

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