| Clinicopathological analysis of myelodysplastic syndrome according to French-American-British classification. | |
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MedLine Citation:
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PMID: 20642923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the age of onset, gender ratio, clinical presentation of Myelodysplastic syndrome patients, and to classify these patients according to French-American-British classification on the basis of morphological features in blood and bone marrow. STUDY DESIGN: A case series. PLACE AND DURATION OF STUDY: The Department of Haematology, Shaikh Zayed Hospital, Lahore, from April 2004 to March, 2007. METHODOLOGY: Fifty patients of primary Myelodysplastic syndrome (MDS) were studied. The patients were classified according to French-American-British (FAB) criteria and the epidemiological, clinical and haematological features of MDS patients were evaluated. Descriptive statistics were used to describe data. RESULTS: There were 31 males and 19 females. The mean age was 41 years. According to FAB classification, 39 cases of refractory anaemia, 1 case of refractory anaemia with ring sideroblast, 6 cases of refractory anaemia with excess of blasts and 4 cases of refractory anaemia with excess of blasts in transformation were identified. The commonest complaint was easy fatiguability affecting 41 cases (82%). Anaemia was the most common finding seen in 47 patients (94%). Pancytopenia was seen in 33 cases (66%). Dyserythropoeisis was present in 42 (84%); dysmyelopoeisis was seen in 21 (42%) and morphologically abnormal megakaryocytes were identified in 29 (58%) of the bone marrow aspirates. Grade- III reticulosis was seen in 9 bone marrow trephine biopsies. Abnormal localization of immature precursors (ALIP) were present in 18 cases. CONCLUSION: MDS was more frequent in young males. Refractory anaemia constituted a major chunk of the disease entity. |
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Authors:
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Ayesha Ehsan; Mona Aziz; Sarah Arif; Muhammad Javed Asif; Tooba Ammar; Shahida Shahida Amjad Riaz Shah |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Volume: 20 ISSN: 1022-386X ISO Abbreviation: J Coll Physicians Surg Pak Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606447 Medline TA: J Coll Physicians Surg Pak Country: Pakistan |
Other Details:
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Languages: eng Pagination: 313-6 Citation Subset: IM |
Affiliation:
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Department of Haematology, Sheikh Zayed Postgraduate Medical Institute, Lahore. ayesha_4@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Cohort Studies England Female France Humans Male Middle Aged Myelodysplastic Syndromes / classification*, diagnosis, epidemiology* Pakistan United States Young Adult |
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