Document Detail


Clinicopathological analysis of mediastinal large B-cell lymphoma and classical Hodgkin lymphoma of the mediastinum.
MedLine Citation:
PMID:  23020783     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Primary mediastinal (thymic) large B-cell lymphoma (PMLBCL) and nodular sclerosis classical Hodgkin lymphoma (NSCHL) are the major histological types of lymphoma affecting the mediastinum. We reviewed 27 patients with PMLBCL and 14 patients with NSCHL. A poor performance status, high serum lactate dehydrogenase level, and strong positivity for PAX5 were all significantly more common in patients with PMLBCL than in those with NSCHL. Severe fibrosis was frequent in NSCHL, but not in PMLBCL. PDL1 was expressed by 11/25 PMLBCLs (44.0%) versus 1/9 NSCHLs (11.1%). Expression of BCL6 was significantly more frequent in PDL1-positive PMLBCL than in PDL1-negative PMLBCL, but there were no clinical differences between these two groups. Two PMLBCL patients with a poor prognosis had CD20(-), CD79a(+), CD15(-), and CD30(-), possibly representing a subtype of mediastinal grey zone lymphoma.
Authors:
Wataru Yamamoto; Naoya Nakamura; Naoto Tomita; Yoshimi Ishii; Hirotaka Takasaki; Chizuko Hashimoto; Shigeki Motomura; Etsuko Yamazaki; Rika Ohshima; Ayumi Numata; Yoshiaki Ishigatsubo; Rika Sakai
Related Documents :
22984493 - Characterization of rheumatoid arthritis subtypes using symptom profiles, clinical chem...
24526513 - Cardioversion of atrial fibrillation (rhythm-af) international registry in poland.
7066033 - Immunomodulating effect of human placenta-eluted gamma globulins in rheumatoid arthritis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-29
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Latex allergy: assessment of knowledge, appropriate use of gloves and prevention practice among hosp...
Next Document:  Altered Brain Metabolism After Whole Body Irradiation in Mice: A Preliminary in vivo (1)H MRS Study.