| Clinicopathological analyses of 5 Japanese patients with CD56+ primary cutaneous lymphomas. | |
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MedLine Citation:
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PMID: 11197216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analyzed the clinicopathological features of 5 Japanese patients with CD56+ primary cutaneous lymphomas (3 men and 2 women aged 25 to 73 years). Except for 1 patient in whom bone marrow involvement was simultaneously observed, all patients presented with cutaneous lesions. Based on their Epstein-Barr virus (EBV) status, we categorized these patients into 2 groups, namely EBV-encoded small RNA-1 (EBER-1) (3 patients) and EBER-1- (2 patients). Generalized lymphadenopathy and bone marrow involvement were observed only in EBER-1 patients. Morphologically, angiocentric proliferation was more prominent in EBER-1+ patients and was accompanied by panniculitis-like changes. The lymphomas in EBER-1- patients featured monomorphic proliferation of lymphoblastic cells with no cytoplasmic granules. Phenotypically, CD3-, cytoplasmic CD3 epsilon+, and CD56+ were common findings in both types. The EBER-1- type showed an additional distinguishing feature, CD7+, CD4+, CD8-, HLA-DR+, and terminal deoxynucleotidyl transferase-positive (TdT+) phenotype. The lymphoma was primarily resistant in the EBER-1+ type, and the patients died within 6 months of admission. In contrast, the lymphoma in the EBER-1- patients was originally chemosensitive. Collectively, we consider there to be at least 2 types of CD56+ primary cutaneous lymphomas, corresponding to nasal-type natural killer (NK)/T-cell lymphomas (EBER-1+) and blastic NK-cell lymphomas (EBER-1-). |
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Authors:
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H Kojima; H Y Mukai; A Shinagawa; C Yoshida; M Kamoshita; T Komeno; Y Hasegawa; Y Yamashita; N Mori; T Nagasawa |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of hematology Volume: 72 ISSN: 0925-5710 ISO Abbreviation: Int. J. Hematol. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-25 Completed Date: 2001-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: Ireland |
Other Details:
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Languages: eng Pagination: 477-83 Citation Subset: IM |
Affiliation:
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Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. hkojima@md.tsukuba.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, CD56* Bone Marrow Neoplasms / etiology, pathology Female Humans Japan Killer Cells, Natural / pathology Lymphoma / classification, pathology*, virology* Male Middle Aged Nose Neoplasms / etiology, pathology, virology RNA, Viral / blood Skin Neoplasms / immunology, pathology, virology* T-Lymphocytes / pathology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD56; 0/Epstein-Barr virus encoded RNA 1; 0/RNA, Viral |
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