Document Detail

Clinicopathological roles of aberrantly expressed recoverin in malignant tumor cells.
MedLine Citation:
PMID:  19887879     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions toward recoverin, a retina-specific calcium binding protein, and other retinal antigens aberrantly expressed in tumor cells are elicited. As a consequence, photoreceptor cell degeneration is induced. To elucidate the pathological role of the aberrantly expressed recoverin, we studied the recoverin expression levels in various malignant tumors and the effects of the expressed recoverin on the sensitivity to anti-cancer drugs. METHODS: Recoverin expression levels were determined by immunohistochemistry with anti-human recoverin monoclonal antibody on multiple tissue arrays obtained from several lung, stomach, colon and other cancers. In the presence of several anti-cancer drugs, including anti-tumor antibiotics, plant alkaloids and anti-metabolites, cytotoxicity assay was performed using recoverin-positive or recoverin-negative A549 cells originating from human lung adenocarcinoma. RESULTS: Immunofluorescence labeling revealed that recoverin immunoreactivities were detected at approximately 10-40% of malignant tumor tissues. Cytotoxic effects by anti-cancer drugs were higher in recoverin-positive A549 cells as compared to recoverin-negative cells. CONCLUSION: The present data may correlate with the previous observation that recoverin-expressing cancer cells induced tumor immunity and a favorable prognosis for primary cancer in CAR patients.
Sachiyo Matsuo; Hiroshi Ohguro; Ikuyo Ohguro; Mitsuru Nakazawa
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Publication Detail:
Type:  Journal Article     Date:  2009-10-30
Journal Detail:
Title:  Ophthalmic research     Volume:  43     ISSN:  1423-0259     ISO Abbreviation:  Ophthalmic Res.     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267442     Medline TA:  Ophthalmic Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan.
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MeSH Terms
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Proliferation
Fluorescent Antibody Technique, Indirect
Gene Expression Regulation, Neoplastic / physiology*
Neoplasms / drug therapy,  genetics*,  pathology*
Recoverin / genetics*,  metabolism
Reg. No./Substance:
0/Antineoplastic Agents; 0/RCVRN protein, human; 135844-11-0/Recoverin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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