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Clinicopathological Characteristics of Extramedullary Acute Megakaryoblastic Leukemia (AMKL): Report of a Case with Initial Mastoid Presentation and Review of Literature to Compare Extramedullary AMKL and Non-AMKL Cases.
MedLine Citation:
PMID:  22667334     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Extramedullary acute megakaryoblastic leukemia (AMKL) is a rare neoplasm with complex clinical presentations and is frequently confused with other small blue cell tumors (SBCT) in pediatric patients. Primary mastoid manifestation of AMKL has never been reported. The extreme rarity of mastoid AMKL combined with the tendency of extramedullary AMKL to mimic other SBCT can create diagnostic challenges. We report a case of primary mastoid AMKL and provide a comprehensive review and analysis that compare the characteristics of extramedullary AMKL and non-megakaryoblastic acute myeloid leukemia (AML) in reported pediatric cases in the past 30 years. We found that patients with extramedullary AMKL were not only younger than patients without megakaryocytic differentiation, but also limited to {less than or equal to}2 years of age. In addition, female was predominant in both AMKL and AML MLL+ groups compared with other types of AML (p = 0.0366 and p = 0.0082). Furthermore, we found that extramedullary AMKL was more likely to have the bone involvement than AML MLL+ (p <0.0001) or other types of AML (p = 0.0002). These evidences suggest that extramedullary AMKL should be considered in the differential diagnosis of SBCT in children, especially in those patients with the mastoid and/or the bone lesions, {less than or equal to}2 years of age, and female gender.
Authors:
Conan Liang; Kenny H Chan; Patricia J Yoon; Mark A Lovell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-5
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Children's Hospital Colorado, Pediatric Otolaryngology.
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