Document Detail

Clinicopathologic studies on neuro-Behçet's disease.
MedLine Citation:
PMID:  4065759     Owner:  NLM     Status:  MEDLINE    
Nine cases of neuro-Behcet's disease were investigated clinicopathologically. Pathological pictures of the central nervous system were characterized as follows: the site of predilection was the brain stem, followed by the spinal cord, cerebrum and cerebellum. The pathognomonic changes were recurrent inflammations around small vessels, causing a softening of the tissue. Lesions were composed of a perivascular infiltration of lymphocytes, histiocytes and microglias and, moreover, diapedesis, degenerated nerve cells and oligodendroglias, glial nodule, breakdown of myelin and axon, fatty granule cells and glio-mesenchymal proliferation were present occasionally. Electron microscopic studies on the neurons revealed no evidence of viral particles except for some accumulations of electron dense bodies.
S Totsuka; T Hattori; M Yazaki; K Nagao; S Mizushima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia psychiatrica et neurologica japonica     Volume:  39     ISSN:  0015-5721     ISO Abbreviation:  Folia Psychiatr Neurol Jpn     Publication Date:  1985  
Date Detail:
Created Date:  1986-01-08     Completed Date:  1986-01-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372774     Medline TA:  Folia Psychiatr Neurol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  155-66     Citation Subset:  IM    
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MeSH Terms
Behcet Syndrome / complications,  pathology*
Brain Stem / pathology
Central Nervous System / pathology*
Cerebellum / pathology
Middle Aged
Nervous System Diseases / complications*,  pathology
Spinal Cord / pathology

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