| Clinicopathologic significance of β-catenin and matrix metalloproteinase-2 expression in non-small cell lung cancer. | |
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MedLine Citation:
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PMID: 23292837 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The purpose of this study was to analyze β-catenin and matrix metalloproteinase-2 (MMP-2) expression in non-small cell lung cancer (NSCLC) and to investigate the association between their expression and clinicopathologic characteristics of NSCLC patients. Immunohistochemistry was performed to examine β-catenin and MMP-2 protein expression in 39 resected NSCLC samples and 8 adjacent normal lung tissues. Statistical analysis with SPSS13.0 software was performed to investigate the association between β-catenin and MMP-2 expression and clinicopathologic features of the patients. Expression of cytosolic β-catenin in NSCLC tissue was significantly higher than that in normal tissues (P < 0.001). In addition, cytosolic protein expression of β-catenin in lung squamous cell carcinoma was significantly elevated compared to that in lung adenocarcinoma (P = 0.02). However, cell membrane protein expression of β-catenin in squamous cell carcinoma was lower than that in adenocarcinoma (P = 0.041). Cytosolic MMP-2 protein expression in NSCLC samples was significantly higher than that in normal tissues (P = 0.002). MMP-2 expression in N (1-2) NSCLC patients was significantly increased relative to N (0) patients (P = 0.019). However, statistical analysis showed no correlation between β-catenin and MMP-2 expression in NSCLC samples. Collectively, our results show that cytosolic protein expression of β-catenin in NSCLC samples is increased relative to normal lung tissues. Also, expression of β-catenin is significantly elevated in squamous cell carcinoma compared to that in lung adenocarcinoma subtypes. Additionally, MMP-2 expression in N (1-2) NSCLC tissues is higher than that in N (0) lung tissue. There is no correlation between β-catenin and MMP-2 expression in NSCLC, and our study suggests that evaluation of β-catenin and MMP-2 expression may have potential in diagnosis and progression in patients with NSCLC. |
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Authors:
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Guang-Hu Li; Yong-Sheng Cui; Qi-Yu Wu; Xiong-Ji Zhang; Yu-Fei Gao |
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Publication Detail:
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Type: Journal Article Date: 2013-01-05 |
Journal Detail:
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Title: Medical oncology (Northwood, London, England) Volume: 30 ISSN: 1559-131X ISO Abbreviation: Med. Oncol. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435512 Medline TA: Med Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 437 Citation Subset: IM |
Affiliation:
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Department of Thoracic Surgery, First Bethune Hospital of Jilin University, Changchun, Jilin, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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