Document Detail

Clinicopathologic risk factors for distant metastases from head and neck squamous cell carcinomas.
MedLine Citation:
PMID:  19616915     Owner:  NLM     Status:  MEDLINE    
AIMS: The aim of this study is to investigate the clinicopathologic risk factors associated with distant metastases (DMs) from head and neck squamous cell carcinomas (HNSCCs). METHODS: Between February 1990 and February 2000, a retrospective analysis of 391 HNSCC patients was performed. The frequency and the clinicopathologic risk factors for DM were evaluated by using univariate chi(2) tests and multiple stepwise logistic regression models. Statistical analysis of overall survival was performed by using Kaplan-Meier method. RESULTS: 44 patients (11.3%) developed DM in clinic. In a univariate analysis, clinical N stage, primary tumor site, level of tumor invasion, pathologic N stage and number of levels with pathologic lymph node were found to be significantly associated with the risk of DM. In a multivariate analysis, the most significant risk factors were number of levels with pathologic lymph node, level of tumor invasion, and primary tumor site. Kaplan-Meier analysis showed that overall survival rates of 44 patients with DMs in clinic were 56.8% at 1 year, 9.1% at 3 years, and 6.8% at 5 years, respectively. CONCLUSIONS: The number of levels with pathologic lymph node, the site of primary tumor and the level of tumor invasion are decisive risk factors in determining the development of DM in head and neck SCC patients. Patients with multilevel nodal involvement in neck, with laryngeal and hypopharyngeal carcinomas, and patients with primary tumor invasion into muscular, bone or cartilage have the highest risk of developing DM.
X Li; B Di; Y Shang; Y Zhou; J Cheng; Z He
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Publication Detail:
Type:  Journal Article     Date:  2009-07-18
Journal Detail:
Title:  European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology     Volume:  35     ISSN:  1532-2157     ISO Abbreviation:  Eur J Surg Oncol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2009-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504356     Medline TA:  Eur J Surg Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1348-53     Citation Subset:  IM    
Department of Otorhinolaryngology, Head and Neck Surgery, Center for Otorhinolaryngological Diseases, Bethune International Peace Hospital, Shijiazhuang 050082, China.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / pathology*,  therapy
Chi-Square Distribution
Head and Neck Neoplasms / pathology*,  therapy
Logistic Models
Lymphatic Metastasis
Middle Aged
Neoplasm Metastasis / pathology*
Neoplasm Staging
Retrospective Studies
Risk Factors
Survival Rate

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