Document Detail


Clinicopathologic implications of the BRAF(V600E) mutation in papillary thyroid cancer: a subgroup analysis of 3130 cases in a single center.
MedLine Citation:
PMID:  23496275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The BRAF mutation has been shown to be associated with aggressive clinicopathologic characteristics of papillary thyroid cancer (PTC). However, several studies that analyzed hundreds of patients have not demonstrated any correlation. The objective of this study was to investigate the relationship of the BRAF mutation with clinicopathologic factors in a large group of homogenous PTC patients.
METHODS: We collected data of PTC patients who received curative resection of the thyroid gland and who had undergone BRAF mutation tests of their thyroid cancer tissue. Minor variant PTCs and mixed-type thyroid cancers were excluded in this analysis. Clinicopathologic characteristics, including age, sex, BRAF mutation, tumor histology, size, extrathyroidal extension, tumor margin, lymph node metastasis, multifocality, stage, and associated thyroid disease, were collected. The relationship of the BRAF mutation with clinicopathologic factors was analyzed in each homogenous histologic PTC.
RESULTS: There were 3130 PTC patients who met the criteria, and these patients were divided into three major histologic groups: conventional PTC (n = 2947), diffuse sclerosing variant PTC (n = 98), and follicular variant PTC (n = 85). The BRAF mutation was variably detected in 75.3%, 61%, and 40% of patients, respectively. In conventional PTC cases, the BRAF mutation was significantly associated with large tumor size, extrathyroidal extension, and lymph node metastasis. Coexistent chronic lymphocytic thyroiditis was significantly less prevalent in the BRAF mutant group. Age, sex, and tumor margin status were not significantly correlated with the BRAF status. There was no evidence that any clinicopathologic factors were linked with the BRAF mutation status in diffuse sclerosing and follicular variant PTCs.
CONCLUSIONS: The BRAF mutation was differentially detected in each histologic subtype of PTC and was strongly correlated with pathologic factors, most strongly with no coexistent chronic lymphocytic thyroiditis, in conventional PTC. The BRAF mutation is suggested to be a poor prognostic marker in conventional PTC, and the BRAF mutational analysis may lead to better management for individual PTC patients.
Authors:
Jae Yun Lim; Soon Won Hong; Yong Sang Lee; Bup-Woo Kim; Cheong Soo Park; Hang-Seok Chang; Jae Yong Cho
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Publication Detail:
Type:  Journal Article     Date:  2013-09-27
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  23     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-07     Completed Date:  2014-06-30     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1423-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma, Follicular / genetics*,  surgery
Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma / genetics*,  surgery
DNA Mutational Analysis
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Mutation*
Polymorphism, Restriction Fragment Length
Prognosis
Proto-Oncogene Proteins B-raf / genetics*
Thyroid Neoplasms / genetics*,  surgery
Thyroiditis / metabolism
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
EC 2.7.11.1/BRAF protein, human; EC 2.7.11.1/Proto-Oncogene Proteins B-raf

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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