Document Detail


Clinicopathologic features and treatment outcomes in malignant lymphoma of pediatric and young adult patients in Korea: comparison of korean all-ages group and Western younger age group.
MedLine Citation:
PMID:  18186966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of this study is to define distinctive clinicopathologic features of malignant lymphoma in pediatric and young adult patients, particularly in Korea. PATIENTS AND METHODS: From May 1993 to November 2005, 294 pediatric and young adult patients (age range, 0-31 years) with malignant lymphoma were analyzed in this study at Samsung Medical Center. We also compared this group with the Korean all-ages group and Western younger age group using previously reported data. RESULTS: Hodgkin disease appears more common in the younger age group than in the all-ages group (15% vs. 5.3%; P = .001). Among patients with non-Hodgkin lymphoma (NHL), T/natural killer cell immunophenotype is more common in the present younger age group than the all-ages group (45.5% vs. 25%; P = .001) and Western younger age group (45.5% vs. 13.3%; P = .001). Lymphoblastic lymphoma and T-anaplastic large-cell lymphoma included relatively higher proportions in the younger age group. Overall survival for patients in the group aged 21-31 years was significantly inferior to that of the other younger age group (P = .014). CONCLUSION: The incidence of Hodgkin disease and T-cell NHL is relatively higher in pediatric and young-adult population group than the all-ages group. However, treatment outcome of the younger age group, excluding lymphoblastic lymphoma, seems to be similar to those in any age group.
Authors:
In Gyu Hwang; Keon Hee Yoo; Soo Hyun Lee; Yeon Hee Park; Tae Kyu Lim; Sang Cheol Lee; Sara Park; Byeong-Bae Park; Young Hyeh Ko; Kihyun Kim; Hong Hoe Koo; Won Seog Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical lymphoma & myeloma     Volume:  7     ISSN:  1557-9190     ISO Abbreviation:  -     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-01-11     Completed Date:  2008-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256500     Medline TA:  Clin Lymphoma Myeloma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  580-6     Citation Subset:  IM    
Affiliation:
Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asian Continental Ancestry Group / statistics & numerical data
Child
European Continental Ancestry Group / statistics & numerical data
Humans
Immunophenotyping
Korea / epidemiology
Lymphoma / epidemiology*,  immunology,  mortality,  pathology*,  therapy
Neoplasm Staging
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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