| Clinicopathologic features of gastrointestinal tract involvement of anaplastic large cell lymphoma. | |
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MedLine Citation:
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PMID: 22776654 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective To investigate the clinicopathological characteristics of gastrointestinal tract involvement of anaplastic large cell lymphoma (ALCL). Methods The clinicopathological features of four patients with ALCL that involved gastrointestinal tract were retrospectively analyzed using immunohistochemical study, T-cell receptor gene rearrangement analysis, and evaluation for Epstein Barr virus infection status. Results Most tumor cells in all these four cases are large and highly pleomorphic, and all four cases were classified as the common pattern ALCL. Tumor cells in all four tumors expressed CD30, and expressed at least one cytotoxic maker. Two patients were confirmed to be with anaplastic lymphoma kinase (ALK)-positive ALCL, and four patients were negative during in situ hybridization for Epstein-Barr virus-encoded RNA but showed clonal T-cell receptor gene rearrangement. Conclusion Gastrointestinal tract involvement of ALCL has the unique clinicopathological features. |
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Authors:
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Sun Jian; Zhou Jiao-Lin; Chen Jie; Lu Chao-Hui |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae Volume: 34 ISSN: 1000-503X ISO Abbreviation: Zhongguo Yi Xue Ke Xue Yuan Xue Bao Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-07-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006230 Medline TA: Zhongguo Yi Xue Ke Xue Yuan Xue Bao Country: China |
Other Details:
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Languages: eng Pagination: 228-33 Citation Subset: IM |
Affiliation:
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Department of Pathology,PUMC Hospital,CAMS and PUMC, Beijing 100730, China. |
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