Document Detail

Clinicopathologic factors associated with involved margins after breast-conserving surgery for invasive lobular carcinoma.
MedLine Citation:
PMID:  20133259     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Obtaining negative margins for patients undergoing breast-conserving surgery (BCS) for invasive lobular carcinoma (ILC) can be difficult because of the unique histologic pattern of ILC. Our goal was to determine whether any specific patient- or disease-related factors influenced margin status. PATIENTS AND METHODS: We retrospectively reviewed 211 patients with ILC treated from 1994 through 2004 to determine if specific clinical and pathologic factors influenced the ability to obtain negative margins. RESULTS: We identified 110 patients (52%) who underwent total mastectomy and 101 (48%) who underwent BCS. Among patients who underwent BCS, 50 (50%) had close or positive margins. Patients with close or positive margins were more likely to have architectural distortion on ultrasonography (vs. mass or calcifications; P = .049), to have undergone excisional biopsy (vs. core or fine-needle aspiration; P = .008), and to have associated ductal carcinoma in situ (P = .021). On multivariate analysis, only biopsy method retained significance (P = .006). CONCLUSION: Core needle biopsy is the preferred method of diagnostic biopsy before surgical intervention. With appropriate patient selection, most patients with early-stage ILC can undergo successful BCS.
Eric J Silberfein; Kelly K Hunt; Kristine Broglio; Jeannie Shen; Aysegul Sahin; Huong Le-Petross; Julia Oh; Jennifer Litton; Rosa F Hwang; Elizabeth A Mittendorf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical breast cancer     Volume:  10     ISSN:  1938-0666     ISO Abbreviation:  Clin. Breast Cancer     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898731     Medline TA:  Clin Breast Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-8     Citation Subset:  IM    
Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
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MeSH Terms
Aged, 80 and over
Antineoplastic Agents / therapeutic use
Biopsy, Needle
Breast Neoplasms / drug therapy,  pathology*,  surgery*
Carcinoma, Lobular / drug therapy,  pathology*,  surgery*
Combined Modality Therapy
Mastectomy, Segmental*
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Reg. No./Substance:
0/Antineoplastic Agents

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