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Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma.
MedLine Citation:
PMID:  21420796     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Beclin-1 has emerged as an autophagy gene in a variety of human carcinomas. The aim of this study was to evaluate beclin-1 expression and to determine its prognostic significance in patients with pancreatic ductal adenocarcinoma (PDA). We performed immunohistochemical staining for beclin-1 in 63 cases of PDA. We investigated whether beclin-1 expression correlated with clinicopathologic characteristics and patient outcomes. Beclin-1 expression was absent in normal pancreatic islet cells, acinar cells, and ductal epithelial cells. In contrast, in PDA, beclin-1 showed positive immunoreactivity in 14 of 63 (22.2%) PDA cases, while the remaining 49 (77.8%) PDA cases exhibited negative beclin-1 expression. We found significant associations between increased beclin-1 expression and the absence of lymphatic invasion (P=0.032) and low rate of distant metastasis (P=0.001). Univariate analysis of survival showed that the median distant metastasis-free survival of beclin-1-negative PDA patients (10 months) was significantly shorter than that of beclin-1-positive PDA patients (21 months; P=0.031). Our results suggest that increased beclin-1 expression plays a role in the inhibition of PDA progression.
Authors:
Hyun-Soo Kim; Sun Ho Lee; Sung-Im Do; Sung-Jig Lim; Yong-Koo Park; Youn Wha Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-18
Journal Detail:
Title:  Pathology, research and practice     Volume:  -     ISSN:  1618-0631     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier GmbH.
Affiliation:
Department of Pathology, Graduate School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, 130-702 Seoul, Republic of Korea.
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