Document Detail


Clinicopathologic characteristics and subsequent pregnancy outcome in 139 complete hydatidiform moles.
MedLine Citation:
PMID:  16530318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The most common form of gestational trophoblastic disease is the complete hydatidiform mole (CHM). The study reports our experience of clinicopathologic characteristics and subsequent pregnancy outcome of patients with CHM. STUDY DESIGN: One hundred fifty-one subsequent cases with initial diagnosis of CHM were re-evaluated histopathologically. Clinical characteristics, the need for chemotherapy and subsequent pregnancy outcome were evaluated. RESULTS: Twelve out of 151 cases were re-evaluated as hydropic abortion, as partial hydatidiform moles or were insufficient for morphologic examination and therefore excluded from further analysis. The leading clinical symptoms of the remaining 139 cases were irregular vaginal bleeding (67%) and uterine enlargement (41%). Twenty-six patients (19%) required chemotherapy because of gestational trophoblastic neoplasia (GTN; low-risk: 23 out of 26). All patients were cured successfully. The subsequent pregnancy rate was 15% (21/139). Five patients suffered from abortions, 12 women delivered a healthy offspring. Four women presented with recurrent CHM with a spontaneous normalization of HCG levels after D&C. CONCLUSIONS: The clinical and morphologic diagnosis of CHM is a challenge, and diagnosis as well as treatment should be multidisciplinary and centralised. One fifth of CHM are at risk of a GTN, but the cure rate is 100% with adequate management. Pregnancy outcome following CHM is complicated by an increased risk of abortion.
Authors:
L-C Horn; J Kowalzik; K Bilek; C E Richter; J Einenkel
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Publication Detail:
Type:  Journal Article     Date:  2006-03-10
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  128     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-09-11     Completed Date:  2007-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  10-4     Citation Subset:  IM    
Affiliation:
Institute of Pathology, Division of Perinatal and Gynecologic Pathology, Leipzig University, Germany. hornl@medizin.uni-leipzig.de
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / etiology
Adolescent
Adult
Female
Humans
Hydatidiform Mole / complications*,  drug therapy,  pathology
Middle Aged
Pregnancy
Pregnancy Outcome*
Recurrence
Retrospective Studies
Uterine Neoplasms / complications*,  drug therapy,  pathology

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