| Clinicopathologic characteristics of polymyositis patients with numerous tissue eosinophils. | |
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MedLine Citation:
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PMID: 8891055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: We evaluated associated clinicopathologic features of polymyositis (PM) patients with numerous tissue eosinophils. MATERIALS AND METHODS: 680 muscle biopsies were examined in our institution and eight were identified with greater than 0.3 eosinophils per square millimeter in the inflammatory infiltrate without concomitant peripheral eosinophilia. RESULTS: All eight patients had typical PM, but neither dermatomyositis nor inclusion body myositis was identified. Clinically, a large number of PM patients with eosinophils manifested an acute- or subacute-onset of symptoms, myoglobinuria, a marked elevation of serum creatine kinase, a good response to steroid therapy, and a relatively benign course compared with 26 PM patients without eosinophils. Muscle biopsies demonstrated necrotic fibers more frequently in PM patients with eosinophils than in PM patients without eosinophils. Hypertrophic fibers, fiber splitting, basophilic fibers, and lobulated fibers were less frequently observed in PM patients with eosinophils. CONCLUSION: These results suggest that the majority of PM patients with eosinophils may be steroid-responsive and suffer an acute or subacute onset of PM. |
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Authors:
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T Kumamoto; H Ueyama; S Fujimoto; S Nagao; T Tsuda |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 94 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-02-06 Completed Date: 1997-02-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 110-4 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Oita Medical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Anti-Inflammatory Agents / therapeutic use Eosinophils / ultrastructure* Female Humans Male Middle Aged Muscle Weakness Muscle, Skeletal / ultrastructure Polymyositis / drug therapy, physiopathology* Steroids |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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