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Clinicopathologic characteristics of T1 colorectal cancer without background adenoma.
MedLine Citation:
PMID:  23294594     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: Background adenoma (BGA) is defined as benign adenomatous tissue contiguous to resected carcinomas, and the absence of BGA in the tumour is considered a histologic criterion of de novo cancers. The present study aimed to identify the clinicopathologic characteristics of T1 colorectal cancer without BGA. METHOD: A retrospective review was carried out of prospectively collected data from two centers: National Cancer Center, Korea and Chonnam National University Hwasun Hospital. A total of 590 patients with T1 colorectal cancer (CRC) treated by endoscopic or surgical resection between January 2001 and August 2011 were enrolled. Details regarding gender, age, tumour location, endoscopic gross type, tumour size, depth of submucosal (SM) invasion, angiolymphatic invasion, tumour grade, budding and lymph node (LN) metastasis were evaluated with regard to the presence or absence of BGA RESULTS: BGA was absent in 197 (33.4%) patients. Tumour size < 20 mm, flat/depressed type, deep SM depth and tumour budding were associated with the absence of BGA in univariate and multivariate analyses (p < 0.05). In surgically resected patients, LN metastases were significantly associated with the absence of BGA (p = 0.022) CONCLUSIONS: T1 CRC without BGA presented several characteristics of small size (< 20 mm), flat/depressed type, deep SM depth (SM 2/3), LN metastasis and tumour budding. These results indicate that de novo cancers may have a more invasive potential. © 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.
Authors:
Kyung Su Han; Sang Woo Lim; Dae Kyung Sohn; Hee Jin Chang; Jae Hwan Oh; Jae Hyuk Lee; Hyeong Rok Kim; Young Jin Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  -     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.
Affiliation:
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
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