Document Detail


Clinicopathologic aspects of gastric neuroendocrine tumors.
MedLine Citation:
PMID:  7762736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The major clinicopathologic aspects of 55 gastric neuroendocrine tumors were analyzed. Forty-six of 55 cases were well-differentiated tumors and 9 were poorly differentiated gastric neuroendocrine carcinomas. Well-differentiated gastric neuroendocrine tumors comprised 1 gastrinoma and 45 enterochromaffin-like (ECL)-cell tumors. ECL tumors were grouped depending on their clinical background. Type 1, associated with chronic atrophic gastritis of the acidopeptic mucosa (A-CAG), included 28 cases with tumor growths mainly restricted to the mucosa and submucosa, with no metastasis. Type 2, associated with hypertrophic gastropathy, included seven cases, six of which were associated with Zollinger-Ellison syndrome (ZES) and multiple endocrine neoplasia type 1 (MEN-1), including two cases with local metastasis. Type 3, not associated with any significant clinicopathologic condition (sporadic), included 10 cases, 7 of which were deeply invasive and 5 metastatic. The nine gastric neuroendocrine carcinomas were highly aggressive metastatic tumors. At follow-up, no tumor-related death was observed for type 1 and type 2 ECL tumors. Type 3 (sporadic) ECL tumors were fatal in 3 of 10 cases, and 6 of 9 patients with gastric neuroendocrine carcinomas died of their tumor disease. It is concluded that type 1 and type 2 well-differentiated ECL tumors are benign or low-grade tumors, whereas type 3 well-differentiated ECL tumors and the poorly differentiated neuroendocrine carcinomas are malignant neoplasms.
Authors:
G Rindi
Related Documents :
7959656 - Gastrointestinal neuroendocrine cell proliferations.
10963516 - High-dose indium 111in pentetreotide radiotherapy for metastatic atypical carcinoid tumor.
3487446 - Upper gastrointestinal bleeding as an unusual presentation of a duodenal carcinoid.
20943646 - Gastrointestinal neuroendocrine tumors.
15056226 - Neuron-specific enolase-producing leiomyosarcoma of the mesentery.
18382356 - Alveolar soft part sarcoma: a bimarker diagnostic strategy using tfe3 immunoassay and a...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  19 Suppl 1     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-06-23     Completed Date:  1995-06-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S20-9     Citation Subset:  IM    
Affiliation:
Gastroenterology Division, New England Medical Center, Boston, Massachusetts, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Gastrins / blood
Humans
Male
Middle Aged
Neuroendocrine Tumors / metabolism,  pathology*
Stomach Neoplasms / metabolism,  pathology*
Grant Support
ID/Acronym/Agency:
TW04781/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Gastrins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hyperplastic, dysplastic, and neoplastic enterochromaffin-like-cell proliferations of the gastric mu...
Next Document:  Helicobacter pylori: a cohort phenomenon.