| Clinicopathologic abnormalities associated with snake envenomation in domestic animals. | |
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MedLine Citation:
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PMID: 21827516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Envenomation of domestic animals by snakes occurs frequently in certain geographic areas. However, reports describing clinical signs, clinicopathologic abnormalities, therapeutic approaches, and outcomes are sparse. This review summarizes various snake families, venom types associated with harmful snakes, and the significant hematologic, hemostatic, and biochemical abnormalities associated with envenomation. Hematologic abnormalities include RBC membrane abnormalities, hemolysis, hemoconcentration, leukogram changes, and platelet abnormalities, specifically thrombocytopenia. Coagulopathies associated with snake envenomation are well described in human medicine, and many studies have demonstrated properties of venoms that lead to both procoagulation and anticoagulation. As expected, similar abnormalities have been described in domestic animals. Biochemical abnormalities are associated with the effects of venom on tissues such as liver, skeletal and cardiac muscle, vascular endothelium, and kidney as well as effects on protein components and cholesterol. This comprehensive review of clinicopathologic abnormalities associated with envenomation and their relationships to characterized venom constituents should be useful both in the diagnosis and management of envenomation and should serve as a foundation for future research in this field. |
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Authors:
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Amelia Goddard; Johan P Schoeman; Andrew L Leisewitz; Salome S Nagel; Itamar Aroch |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-08-09 |
Journal Detail:
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Title: Veterinary clinical pathology / American Society for Veterinary Clinical Pathology Volume: 40 ISSN: 1939-165X ISO Abbreviation: Vet Clin Pathol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-02 Completed Date: 2012-04-17 Revised Date: 2012-10-04 |
Medline Journal Info:
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Nlm Unique ID: 9880575 Medline TA: Vet Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 282-92 Citation Subset: IM |
Copyright Information:
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©2011 American Society for Veterinary Clinical Pathology. |
Affiliation:
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Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa. amelia.goddard@up.ac.za |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Domestic* Blood Coagulation / drug effects Blood Platelets / pathology Erythrocytes / pathology Hemolysis / drug effects Hemostasis / drug effects Leukocytes / pathology Snake Bites / blood, pathology, veterinary* Snake Venoms / adverse effects, classification* Snakes / classification* Thrombocytopenia / blood, veterinary |
| Chemical | |
Reg. No./Substance:
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0/Snake Venoms |
| Comments/Corrections | |
Erratum In:
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Vet Clin Pathol. 2012 Mar;41(1):169 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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