Document Detail


Clinicopathologic prognostic factors of pure myxoid liposarcoma of the extremities and trunk wall.
MedLine Citation:
PMID:  20499293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Myxoid liposarcoma is generally considered a low grade tumor but the presence of areas of round cells exceeding 5% is reportedly associated with a worse prognosis. Whether "pure" tumors without round cells are low grade has not been confirmed. While radiotherapy has been used for patients' myxoid liposarcoma it is unclear whether it reduces local recurrences.
QUESTIONS/PURPOSES: We therefore determined the survival, roles of radiotherapy for local control, and prognostic factors of pure myxoid liposarcoma of the extremities and trunk wall.
METHODS: We retrospectively reviewed 53 patients histologically diagnosed with pure myxoid liposarcoma arising in extremities and the trunk wall. Nine patients of the 53 received radiotherapy for primary tumors. Clinical features and prognosis was determined, and various factors were analyzed as to their usefulness as prognostic factors (age, gender, location, size, depth, surgical margin, and adjuvant radiotherapy). The minimum followup was 12 months (mean, 60 months; range, 12-226 months).
RESULTS: Seven (13%) and 6 (11%) patients developed a local recurrence and distant metastasis, respectively. The 5- and 10-year disease-specific and disease-free survival rates were 90% and 83% and 77% and 77%, respectively. Radiotherapy had no impact on either overall or disease free survival. Age (older than 60 years) independently predicted worse overall and disease-free survival.
CONCLUSIONS: In pure myxoid liposarcoma located in the extremities and trunk wall, relatively few patients developed distant metastasis suggesting the tumor is generally low grade. Local control could be achieved with wide surgical margins without radiotherapy. Age was associated with lower survival but size and depth were not. Myxoid liposarcoma in older patients requires special consideration for treatment and followup.
Authors:
Yoshihiro Nishida; Satoshi Tsukushi; Hiroatsu Nakashima; Naoki Ishiguro
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  468     ISSN:  1528-1132     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2010-10-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3041-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan. ynishida@med.nagoya-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Disease-Free Survival
Extremities
Female
Humans
Japan
Kaplan-Meier Estimate
Liposarcoma, Myxoid / mortality,  secondary,  surgery*
Male
Middle Aged
Neoplasm Recurrence, Local / mortality,  prevention & control
Orthopedic Procedures*
Proportional Hazards Models
Radiotherapy, Adjuvant
Retrospective Studies
Risk Assessment
Risk Factors
Soft Tissue Neoplasms / mortality,  pathology,  surgery*
Survival Rate
Time Factors
Treatment Outcome
Young Adult
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