Document Detail

Clinico-radiological correlates of achalasia.
MedLine Citation:
PMID:  15711665     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the clinical and radiographic characteristics of achalasia in a cohort Jordanian patients and to investigate the presence of any clinico-radiological relationships. METHODS: Thirty-five cases of recently diagnosed untreated achalasia patients were studied at Jordan University Hospital, Amman, Jordan during the period of January 1999 to December 2002. Measurements of maximum esophageal and gastroesophageal (GE) junction diameters, as radiographic features, were obtained from films. The clinical features included age; gender; nature; frequency and duration of typical and atypical symptoms; total number of symptoms; calculated typical symptoms score; and diagnostic delay. Pearson correlation coefficients were calculated between radiographic and clinical features, and among the radiographic features themselves. Using Spearman's correlation coefficients, the later analysis was repeated for patients with diagnostic delay of 2 years or less and patients with more than 2 years. All results were evaluated based on the 0.05 level of significance. RESULTS: There were 35 consecutive achalasia patients enrolled in this study (20 females and 15 males) with a mean age of 42.3 +/- 15.6 years and diagnostic delay of 29 +/- 26 months. On average, each patient has presented 2 typical symptoms and 2 atypical symptoms. The mean typical symptoms score was almost 3 out of the full score of 6. The mean GE junction diameter was 2.4 mms and maximum esophageal diameter was 29 mms. Maximum esophageal diameter was significantly correlated with the number of typical, atypical and total symptoms as well as with the typical symptom score and diagnostic delay. Negative correlation was found between GE junction diameter and maximum esophageal diameter; but only statistically significant for patients with diagnostic delay of more than 2 years. CONCLUSION: Statistically significant relationship exists between maximum esophageal diameter and all clinical variables. Negative correlation exists between maximum esophageal diameter and GE junction diameter; however, only significant for patients with a diagnostic delay more than 2 years. The possibility of achalasia is high in patients with longer diagnostic delay who demonstrate negative relationship between maximum esophageal diameter and GE junction diameter.
Emad S Tarawneh; Waleed S Mahafzah; Azmi A Haroun; Azmy M Hadidy; Mustafa M Shennak
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  25     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-15     Completed Date:  2005-04-08     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1909-12     Citation Subset:  IM    
Department of Diagnostic Radiology and Gastroenterology Unit, Jordan University, PO Box 13200, Amman 11942, Jordan.
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MeSH Terms
Cohort Studies
Diagnosis, Differential
Esophageal Achalasia / radiography*
Esophagogastric Junction / radiography
Middle Aged
Predictive Value of Tests
Prospective Studies
Statistics as Topic

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