Document Detail

Clinico-pathological study of cerebral aneurysms.
MedLine Citation:
PMID:  15069246     Owner:  NLM     Status:  MEDLINE    
AIMS AND OBJECTIVES: A clinico-pathological study of cerebral aneurysms was undertaken to understand the histopathogical nature of the lesions and to ascertain possible etiological risk factors. MATERIAL AND METHODS: Of the 255 cases of cerebral aneurysms operated upon at our Institute during the two-year period between Jan 1999 to Dec 2000, a detailed study was conducted on 57 cases where the aneurysm sac could be excised and subjected to histopathological examination. Aneurysm sacs were fixed in 10% buffered formaldehyde and processed through graded alcohol. Paraffin-embedded sections were examined, using hematoxylin and eosin, Verhoeff van Gieson's and toluidine blue staining techniques. Histopathological observations were analyzed and correlated with clinical features. RESULTS: The ages of the patients ranged from 17-65 years and there were 33 males and 24 females. Twenty-six patients were chronic smokers and 19 patients had hypertension. There were 54 saccular and 3 fusiform aneurysms, predominantly involving the anterior circulation (52 cases) than posterior circulation (5 cases). In 35 cases, histopathological studies demonstrated mucoid deposits between hyperplastic cellular elements in the true and false aneurysm wall and/or parent artery or vasavasora. The changes were associated with dystrophic changes in the internal elastic lamina. CONCLUSION: Besides significant risk factors like smoking and hypertension, such mucoid vasculopathic changes may have predisposed vessels to structural weakness and aneurysm formation in our patients.
B J Rajesh; S Sandhyamani; R N Bhattacharya
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology India     Volume:  52     ISSN:  0028-3886     ISO Abbreviation:  Neurol India     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-07     Completed Date:  2004-11-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0042005     Medline TA:  Neurol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  82-6     Citation Subset:  IM    
Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
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MeSH Terms
Aneurysm, Ruptured / pathology
Brain / pathology
Child, Preschool
Intracranial Aneurysm / diagnosis,  pathology*,  surgery
Middle Aged
Mucous Membrane / pathology
Neurosurgical Procedures
Risk Factors
Sex Characteristics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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