Document Detail

Clinico-pathological correlations in fatal ischemic stroke. An immunohistochemical study of human brain penumbra.
MedLine Citation:
PMID:  21424029     Owner:  NLM     Status:  In-Data-Review    
Ischemic stroke is one of the most frequent pathologies with high invalidating potential and a leading cause of death. The brain tissue adjacent to the central necrotic core, defined as penumbra, was extensively characterized mostly by imaging techniques and in animal models. Our goal was to identify a large panel of molecules in this particular area on human brains harvested at autopsy. Twenty-one patients with ischemic stroke and seven control cases were taken into study. We used immunohistochemistry to characterize necrotic lesions. Metalloproteinases, mostly MMP-9, seem to be involved in brain ischemia, but as a protective and not as a deleterious factor. Apoptotic molecules are not increasingly expressed in stroke compared to control cases. Mast cell enzymes chymase and tryptase are described for the first time in neurons and glia, even with unclear significance. Microglia appears active in stroke and stimulating methods directed to it could be useful. Nitric oxide synthases and cyclooxygenase-2 were also involved in stroke cases but not in control ones. Other factors as VEGF and its receptors, PDGF, b-FGF or TNF-alpha showed no significant expression related to ischemic brain injury. Animal study of penumbra and human tissue findings are distinct and research should be focused on the latter approach in order to find valuable and safe therapeutic methods.
D Arsene; Florina Vasilescu; C Toader; Adina Bălan; C Popa; Carmen Ardeleanu
Related Documents :
21331249 - Homing pigeons as a model for the influence of experience on brain composition-includin...
21486299 - Concepts and principles in the analysis of brain networks.
22286499 - Comparison of Δfosb immunoreactivity induced by vagal nerve stimulation with that cause...
21527759 - Molecular pathophysiology of cerebral hemorrhage: secondary brain injury.
3808889 - Perceptions by the aged of crime, criminals, and the criminal justice system.
21091949 - How hardwired is the brain? technological advances provide new insight into brain malle...
11849559 - Progressive supranuclear palsy: neuronal and glial cytoskeletal pathology in the higher...
14625039 - Long-term changes of activity of cortical neurons after status epilepticus induced at e...
24399949 - Functional brain imaging using near-infrared spectroscopy during actual driving on an e...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie     Volume:  52     ISSN:  1220-0522     ISO Abbreviation:  Rom J Morphol Embryol     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112454     Medline TA:  Rom J Morphol Embryol     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  29-38     Citation Subset:  IM    
Department of Histopathology and Immunohistochemistry, "Victor Babes" National Institute of Pathology, Bucharest, Romania;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inflammation in COPD: pathogenesis, local and systemic effects.
Next Document:  Immunohistochemical evaluation of COX-2 expression in HPV-positive cervical squamous intraepithelial...