Document Detail


Clinico-myocological profile of tinea capitis in North India and response to griseofulvin.
MedLine Citation:
PMID:  11280460     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is a paucity of literature on tinea capitis from North India. The response to griseofulvin has not been studied as well. We studied 153 consecutive patients of tinea capitis for clinical patterns, causative dermatophytic species, clinico-etiological correlation, and response to griseofulvin. Culture and sensitivity were done on all patients. All patients were treated with griseofulvin for 6-8 weeks; non-responders were further treated with fluconazole. Ninety percent of the patients were less than 15 years of age, 75% belonged to poor socioeconomic groups and 19% had a family history of tinea capitis. The seborrheic variant was the commonest clinical pattern seen in 47.8% of patients, followed by grey patch, black dot, kerion, and alopecia-areata-like tinea capitis in 35.9%, 8.5%, 6.5% and 1.3% of patients, respectively. Only 66% of patients had a positive culture. T. violaceum was the commonest dermatophytic species isolated in 38% patients. M. audouinii, T. schoenleinii, T. tonsurans, M. gypseum, T. verrucosum and T. mentagrophytes were isolated in 34%, 10%, 9%, 3%, 3% and 3% of patients, respectively. Of the isolates 94% were susceptible to griseofulvin, and 100% were susceptible to fluconazole. By using griseofulvin for 6-8 weeks 97.4% of the patients were cured; nonresponders required therapy with fluconazole for cure. To conclude, tinea capitis is still a disease of younger people of poor socioeconomic status. T. violaceum and M. audouinii are the most common responsible dermatophytes. The response to griseofulvin was excellent, and it should be used as a first line therapy.
Authors:
A Singal; S Rawat; S N Bhattacharya; S Mohanty; M C Baruah
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  28     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-30     Completed Date:  2001-05-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of College of Medical Sciences, New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antifungal Agents / therapeutic use*
Child
Child, Preschool
Female
Griseofulvin / therapeutic use*
Humans
India / epidemiology
Infant
Male
Tinea Capitis / drug therapy*,  epidemiology*,  microbiology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antifungal Agents; 126-07-8/Griseofulvin

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