Document Detail

Clinically successful late recanalization of basilar artery occlusion in childhood: what are the odds? Case report and review of the literature.
MedLine Citation:
PMID:  17482211     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Acute basilar artery occlusion is an infrequent but potentially fatal cause of stroke, both in adults and children. We present our experience with a 6-year-old child and we investigate the rationality for late treatment of acute basilar occlusion in children. METHODS: We report the case of a 6-year-old boy with acute basilar artery occlusion presented with a full blown locked-in syndrome, admitted to the endovascular suite 44 h after the stroke onset, and we review all the reported cases of basilar artery occlusions presented with locked-in syndrome in children. RESULTS: Six hours following admission the basilar artery was partially recanalized by intra-arterial thrombolysis combined with mechanical clot angioplasty. After 12 h, the patient was awake, oriented, his speech function was fully restored and he had only a mild right hemiparesis that recovered completely after a month. CONCLUSIONS: To our knowledge, this is the first report of complete clinical recovery after delayed (50 h) endovascular recanalization of basilar artery in a child. Intra-arterial thrombolysis combined with cerebral angioplasty, can successfully restore the patency of the basilar artery and the neurologic deficit of children with acute basilar artery occlusion, even after a considerable delay.
Savvas Grigoriadis; John Mose Gomori; Nikolaos Grigoriadis; José E Cohen
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-05-04
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  260     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-12-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
Hadassah Stroke Center, Hadassah University Hospital, Jerusalem, Israel.
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MeSH Terms
Age Factors
Angioplasty, Balloon / methods*,  trends
Anticoagulants / administration & dosage
Basilar Artery / pathology,  radiography,  surgery*
Brain Stem Infarctions / etiology,  pathology,  therapy*
Heparin / administration & dosage
Pons / blood supply,  pathology,  physiopathology
Quadriplegia / etiology,  pathology,  therapy
Thrombolytic Therapy / methods*,  trends
Time Factors
Treatment Outcome
Urokinase-Type Plasminogen Activator / administration & dosage
Vertebrobasilar Insufficiency / complications,  pathology,  therapy*
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin; EC Plasminogen Activator

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