Document Detail

Clinically silent adrenal adenomas - their relation to the metabolic syndrome and to GNB3 C825T gene polymorphism.
MedLine Citation:
PMID:  21979884     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Aim of the study was to assess the prevalence of C825T GNB3 gene polymorphism in patients with adrenal incidentaloma (AI) as well as its relation to the metabolic syndrome (MS) and cortisol status. SUBJECT AND METHODS: Alltogether 82 subjects (50 patients with AI, mean age 57.9 + 15 years and 32 subjects without AI, mean age 53.8 + 6.9 years) were included in this study. Parameters of glucose and lipid metabolism, serum adiponectin and the single nucleotide polymorphism C825T in GNB3 gene using PCR-RFLP method were examined. To detect subclinical Cushing syndrome an overnight dexamethason test was performed in all patients with AI. RESULTS: Patients with AI had signifcantly higher BMI, HOMA, triacylglycerols (p < 0.05) and significantly lower serum adiponectine (p < 0.05) than controls. There were no significant differences in metabolic parameters between group with and without subclinical Cushing syndrome (SCS). The prevalence of T allele of GNB3 gene in patients with AI was not significantly higher as compared with control group (32% vs. 47%). No significant differences in serum glucose and lipids between carriers of T and C alleles were detected. However carriers of T allele had significantly lower serum adiponectin than those with allele C (p < 0.01). CONCLUSION: We conclude that patients with AI had significantly higher cardiovascular risk factors that is not related to the presence of SCS. Moreover patients with AI and TC or TT genotype have significantly lower serum adiponectin which may be an early symptom of metabolic syndrome in patients with AI.
Ivica Lazúrová; Daniela Spišáková; Hedviga Wagnerová; Viera Habalová; Ingrid Dravecká; Petrášová Darina; Ivica Drahovská; Lýdia Pundová
Related Documents :
22853724 - Usefulness of acarbose and dietary modifications to limit glycemic variability followin...
2358644 - The risk of urinary tract infection in bowel incontinent men.
8996364 - Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting cl...
18844264 - Importance of extrasphincteric mechanisms in the pathophysiology of faecal incontinence...
15935384 - Abnormalities on ecg and telemetry predict stroke outcome at 3 months.
20655174 - Memory b-cell aggregates in skin biopsy are diagnostic for primary sjögren's syndrome.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-10
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  -     ISSN:  1613-7671     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1st Department of Internal Medicine, Medical Faculty P. J. Šafárik University, Košice, Slovakia,
Vernacular Title:
Klinisch stumme Nebennieren Adenome: Ihre Beziehung zum metabolischen Syndrom und zum GNB3 C825T Gen Polymorphismus.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Use of water sources by buffy-headed marmosets (Callithrix flaviceps) at two sites in the Brazilian ...
Next Document:  Primary spontaneous pneumothorax and mitral valve prolapse are not associated.