Document Detail

Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation.
MedLine Citation:
PMID:  20858859     Owner:  NLM     Status:  In-Process    
This study assessed the cumulative incidence of clinically significant cardiac disease in 1279 Hodgkin lymphoma patients treated with mediastinal irradiation and quantified the standard incidence ratios (SIRs) and absolute excess risks of cardiac procedures compared with a normal matched population. Cox regression analysis was used to explore factors associated with cardiac complications. Poisson regression analysis of SIRs was used to estimate the excess risk of cardiac interventions from mediastinal irradiation. After a median follow-up of 14.7 years, 187 patients experienced 636 cardiac events and 89 patients required a cardiac procedure. 5-, 10-, 15-, and 20-year cumulative incidence rates of cardiac events were 2.2%, 4.5%, 9.6%, and 16%. SIRs for cardiac procedures were increased for coronary artery bypass graft (3.19), percutaneous intervention (1.55), implantable cardioverter defibrillator or pacemaker placement (1.9), valve surgery (9.19), and pericardial surgery (12.91). Absolute excess risks were 18.2, 19.3, 9.4, 14.1, and 4.7 per 10 000 person-years, respectively. Older age at diagnosis and male sex were predictors for cardiac events. However, younger age at diagnosis was associated with excess risk specifically from radiation therapy compared with the general population. These results may help guideline development for both the types and timing of cardiac surveillance in survivors of Hodgkin lymphoma.
Shira L Galper; James B Yu; Peter M Mauch; Jon F Strasser; Barbara Silver; Ann Lacasce; Karen J Marcus; Mary Ann Stevenson; Ming Hui Chen; Andrea K Ng
Related Documents :
2439559 - Prognostic significance of ventricular ectopic activity in survivors of acute myocardia...
10884669 - The changing pattern of reoperative coronary surgery: trends in 1230 consecutive reoper...
22381159 - How the 2008 stock market crash and seasons affect total and cardiac deaths in los ange...
24959979 - Correction: culprit vessel only versus multivessel percutaneous coronary intervention i...
14597929 - Association of the pursuit risk score with predischarge ejection fraction, angiographic...
9124159 - The natural history of single-vessel chronic coronary occlusion: a 25-year experience.
8721699 - Contrast cine left ventriculography: comparison of two pigtail catheter shapes and anal...
2882869 - A pathophysiologic basis for the clinical classification and management of unstable ang...
18163779 - Vulnerability to re-entry in simulated two-dimensional cardiac tissue: effects of elect...
Publication Detail:
Type:  Journal Article     Date:  2010-09-21
Journal Detail:
Title:  Blood     Volume:  117     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  412-8     Citation Subset:  AIM; IM    
Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomo...
Next Document:  Adhesive epicardial corticosteroids prevent postoperative atrial fibrillation.