Document Detail

Clinically safe dosage of felypressin for patients with essential hypertension.
MedLine Citation:
PMID:  10323116     Owner:  NLM     Status:  MEDLINE    
Hemodynamic changes were evaluated in patients with essential hypertension when felypressin of various concentrations was administered. The parameters studied were systolic pressure, diastolic pressure, heart rate, left ventricular systolic phase, and endocardial viability ratio. Results showed that blood pressure tended to increase, and the value of 1/pre-ejection period2 (PEP2) tended to decrease, upon administration of 3 ml of 2% propitocaine containing 0.06 international units/ml (IU/ml) of felypressin. Significant increase of blood pressure and decrease in 1/PEP2 was noted upon administration of 3 ml of anesthetic solution containing 0.13 IU/ml of felypressin. No ischemic change of the myocardium was detected even with the highest felypressin concentration (3 ml of 2% propitocaine containing 0.25 IU/ml of felypressin). These results suggest that the clinically safe dosage of felypressin for patients with essential hypertension is approximately 0.18 IU. This amount is equivalent to 6 ml of 3% propitocaine with 0.03 IU/ml of felypressin, which is a commercially available local anesthetic for dental use. It seems that the decrease in 1/PEP2 that occurred during blood pressure increase was due to the increase in afterload caused by contraction of the arterioles. Although in the present study no ischemic change was noted, special care should be taken to prevent myocardial ischemia in patients with severe hypertension.
K Sunada; K Nakamura; M Yamashiro; M Sumitomo; H Furuya
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Anesthesia progress     Volume:  43     ISSN:  0003-3006     ISO Abbreviation:  Anesth Prog     Publication Date:  1996  
Date Detail:
Created Date:  1999-05-18     Completed Date:  1999-05-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0043533     Medline TA:  Anesth Prog     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  108-15     Citation Subset:  D    
Department of Anesthesiology, Nippon Dental University, School of Dentistry at Tokyo, Japan.
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MeSH Terms
Analysis of Variance
Anesthesia, Local
Chi-Square Distribution
Dental Care for Chronically Ill*
Diastole / drug effects
Dose-Response Relationship, Drug
Felypressin / administration & dosage*
Hemodynamics / drug effects*
Hypertension* / physiopathology
Mandibular Nerve
Middle Aged
Nerve Block
Systole / drug effects
Vasoconstrictor Agents / administration & dosage*
Reg. No./Substance:
0/Vasoconstrictor Agents; 56-59-7/Felypressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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