Document Detail


Clinically isolated syndromes suggestive of multiple sclerosis, part 2: non-conventional MRI, recovery processes, and management.
MedLine Citation:
PMID:  15907738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The onset of multiple sclerosis (MS) in 85% of young adults is with a subacute clinically isolated syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Whereas multifocal brain lesions are present on MRI in many patients with a CIS, some patients have additional abnormalities on quantitative MRI in otherwise normal-appearing white and grey matter that suggest an extensive pathological process. Functional outcome for patients with symptomatic CIS lesions is determined by the interplay of inflammation, demyelination, axonal damage, remyelination, and cortical adaptation. Recovery of function may be accelerated by high dose corticosteroids, and although interferon beta delays the development of a second relapse, its long-term effect is unknown. A better understanding of pathological and pathogenetic processes in patients with a CIS will facilitate the development of disease-modifying treatments for patients with MS before they become disabled. Continued clinical and laboratory investigation of patients with a CIS should be encouraged.
Authors:
David Miller; Frederik Barkhof; Xavier Montalban; Alan Thompson; Massimo Filippi
Related Documents :
15906348 - Diffusion tensor fractional anisotropy of the normal-appearing seven segments of the co...
17235368 - P-wave duration and dispersion in patients with peripheral edema and its amelioration.
15717628 - Influence of ischemia on heart-rate variability in chronic hemodialysis patients.
11328198 - Interleukin-1beta converting enzyme/caspase-1 (ice/caspase-1) and soluble apo-1/fas/cd ...
21720528 - A patient with fragile x-associated tremor/ataxia syndrome presenting with executive co...
15153218 - Anaesthetic management of infants with glycogen storage disease type ii: a physiologica...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Lancet. Neurology     Volume:  4     ISSN:  1474-4422     ISO Abbreviation:  Lancet Neurol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-23     Completed Date:  2005-06-22     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  341-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Disease Management
Humans
Magnetic Resonance Imaging / methods*
Multiple Sclerosis / diagnosis*,  drug therapy*
Recovery of Function / physiology*
Syndrome
Grant Support
ID/Acronym/Agency:
748//Multiple Sclerosis Society

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Quality of life in patients with localized prostate cancer.
Next Document:  Sensory neuron diseases.