Document Detail

Clinically isolated syndromes suggestive of multiple sclerosis, part 2: non-conventional MRI, recovery processes, and management.
MedLine Citation:
PMID:  15907738     Owner:  NLM     Status:  MEDLINE    
The onset of multiple sclerosis (MS) in 85% of young adults is with a subacute clinically isolated syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Whereas multifocal brain lesions are present on MRI in many patients with a CIS, some patients have additional abnormalities on quantitative MRI in otherwise normal-appearing white and grey matter that suggest an extensive pathological process. Functional outcome for patients with symptomatic CIS lesions is determined by the interplay of inflammation, demyelination, axonal damage, remyelination, and cortical adaptation. Recovery of function may be accelerated by high dose corticosteroids, and although interferon beta delays the development of a second relapse, its long-term effect is unknown. A better understanding of pathological and pathogenetic processes in patients with a CIS will facilitate the development of disease-modifying treatments for patients with MS before they become disabled. Continued clinical and laboratory investigation of patients with a CIS should be encouraged.
David Miller; Frederik Barkhof; Xavier Montalban; Alan Thompson; Massimo Filippi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Lancet. Neurology     Volume:  4     ISSN:  1474-4422     ISO Abbreviation:  Lancet Neurol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-23     Completed Date:  2005-06-22     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  341-8     Citation Subset:  IM    
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MeSH Terms
Disease Management
Magnetic Resonance Imaging / methods*
Multiple Sclerosis / diagnosis*,  drug therapy*
Recovery of Function / physiology*
Grant Support
748//Multiple Sclerosis Society

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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