| Clinically significant variability of serum IgE concentrations in patients with severe asthma. | |
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MedLine Citation:
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PMID: 22277088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the magnitude of immunoglobulin E (IgE) variability in a cohort of patients with severe asthma considered for omalizumab therapy. METHODS: Retrospective chart review identified 65 patients with two or more IgE determinations out of the 124 patients referred to the Cleveland Clinic Respiratory Institute for treatment with omalizumab from 2003 to 2011. Patients with conditions known to affect IgE concentrations were excluded. Demographic data, pulmonary function testing, medications, smoking status, and atopy were recorded. The range of variability and percent variability in relation to baseline serum IgE were calculated. RESULTS: The median difference of serum IgE between the minimal and maximal values was 94.9 IU/ml (IQR 26.3-324.1 IU/ml). Percent variability from minimum value had a median of 75.5% (IQR 23.3-152.6%). There was no correlation between age, body mass index, lung function, and IgE variability. Greater variability was associated with female gender (p = .06). There was no association with peripheral eosinophilia, systemic corticosteroid use, and leukotriene modifier use at presentation. The observed variability would have affected omalizumab dosing in 20 out of 42 patients. Six patients who may have qualified at different time points would not have been deemed candidates based on an IgE concentration <30 IU/ml or >700 IU/ml. CONCLUSION: Serum IgE concentration may have clinically significant variability over time, affecting candidacy and dosing of omalizumab. Our findings imply that repeating serum IgE determinations merits consideration for patients whose initial concentrations are <30 or >700 IU/ml. Prospective studies are warranted to delineate the factors that contribute to IgE variability. |
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Authors:
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Srinivas R Mummadi; Umur Sevket Hatipoğlu; Manjula Gupta; Mary Kay Bossard; Meng Xu; David Lang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-01-25 |
Journal Detail:
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Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: 49 ISSN: 1532-4303 ISO Abbreviation: J Asthma Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-09 Completed Date: 2012-03-26 Revised Date: 2013-01-18 |
Medline Journal Info:
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Nlm Unique ID: 8106454 Medline TA: J Asthma Country: England |
Other Details:
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Languages: eng Pagination: 115-20 Citation Subset: IM |
Affiliation:
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Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Anti-Idiotypic / therapeutic use Asthma / immunology* Female Humans Immunoglobulin E / blood* Male Middle Aged Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/anti-IgE antibodies; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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