Document Detail

Clinically asymptomatic vascular brain injury: a potent cause of cognitive impairment among older individuals.
MedLine Citation:
PMID:  23034523     Owner:  NLM     Status:  MEDLINE    
Cerebrovascular risk factors and stroke are highly prevalent with advancing age, and stroke may be more common than Alzheimer's disease, particularly among older men. While stroke mortality continues to decline, the prevalence of individuals with various vascular risk factors continues to rise and many are undiagnosed or undertreated. Asymptomatic cerebrovascular brain injury that includes asymptomatic brain infarction and white matter hyperintensities as well as accelerated brain atrophy is even more frequent than clinical stroke. Moreover, the impact of cerebrovascular risk factors on brain injury appears to begin in middle life and additively increases the likelihood of later life dementia. This review focuses on the use of neuroimaging and genetics to understand the impact of asymptomatic vascular risk factors on the trajectories of cognitive aging as well as incident cognitive impairment, stroke, and mortality. Results of this review emphasize the need for early detection and treatment of vascular risk factors to improve the cognitive health of our rapidly aging population.
Charles DeCarli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  33 Suppl 1     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2013  
Date Detail:
Created Date:  2012-12-28     Completed Date:  2013-06-06     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  S417-26     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Aging / genetics,  pathology
Brain / pathology
Cerebrovascular Disorders / complications*,  epidemiology,  genetics,  pathology
Cognition Disorders / epidemiology,  etiology*,  genetics,  pathology
Risk Factors
Grant Support
P30 AG010129/AG/NIA NIH HHS; P30 AG10129/AG/NIA NIH HHS; R01 AG021028/AG/NIA NIH HHS

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