Document Detail


Clinical value of pancreatitis-associated protein in acute pancreatitis.
MedLine Citation:
PMID:  9382059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Pancreatitis-associated protein (PAP) is a secretory protein that is overexpressed by the pancreas during acute pancreatitis. This study was carried out to assess the clinical value of PAP in acute pancreatitis, particularly its ability to indicate the severity of the disease. METHODS: Twenty-one healthy subjects, 58 patients with acute pancreatitis, and 20 patients with nonpancreatic acute abdomen were studied. In addition to serum PAP concentration, serum concentrations of amylase, lipase, and C-reactive protein (CRP) were measured at admission and, in patients with acute pancreatitis, during the following 5 days. RESULTS: On admission, serum PAP concentrations were abnormally high in 46 of the 58 patients with acute pancreatitis (79%); serum amylase, in 57 patients (98%); serum lipase, in all patients (100%); and serum CRP, in 40 patients (69%). During the subsequent days of the study, PAP and CRP tended to increase, whereas amylase and lipase decreased. No significant differences in PAP or amylase and lipase concentrations were found between patients with mild pancreatitis and those with severe pancreatitis during the entire study period, whereas from the third day to the sixth day, CRP concentrations were significantly higher in patients with severe pancreatitis than in those with mild pancreatitis. Among the 20 patients with nonpancreatic acute abdomen, PAP concentrations were abnormally high in 10 (50%), whereas amylase concentrations were abnormally high in five (25%), and lipase concentrations were high in two (10%). CONCLUSIONS: Our results indicate that the clinical value of PAP in acute pancreatitis is quite limited and, in particular, that PAP is not a useful marker for determining the severity of the disease.
Authors:
R Pezzilli; P Billi; M Migliori; L Gullo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  92     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-12     Completed Date:  1997-11-12     Revised Date:  2010-02-08    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1887-90     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Gastroenterology, University of Bologna, Sant' Orsola Hospital, Italy.
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MeSH Terms
Descriptor/Qualifier:
Abdomen, Acute / blood
Acute Disease
Acute-Phase Proteins / analysis*
Adult
Aged
Aged, 80 and over
Amylases / blood
Antigens, Neoplasm*
Biological Markers / blood
C-Reactive Protein / analysis
Female
Humans
Lectins, C-Type*
Lipase / blood
Male
Middle Aged
Pancreatitis / blood*,  diagnosis
Tumor Markers, Biological*
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Antigens, Neoplasm; 0/Biological Markers; 0/Lectins, C-Type; 0/Tumor Markers, Biological; 0/pancreatitis-associated protein; 9007-41-4/C-Reactive Protein; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases

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