| Clinical value of myocardial perfusion scintigraphy as a screening tool in liver transplant candidates. | |
| | |
MedLine Citation:
|
PMID: 21384508 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
A cardiac evaluation before orthotopic liver transplantation (OLT) is imperative. Previous investigations have demonstrated that mild to moderate reversible perfusion defects on myocardial perfusion scintigraphy (MPS) in general are associated with a low risk for perioperative cardiac events. The objective of this study was to assess any perfusion defects in consecutive patients with chronic liver disease who were undergoing OLT. OLT candidates underwent extensive cardiovascular screening that included, among other methods, MPS. Patients who had no contraindications for surgery and underwent OLT were followed up. The occurrence and risk of complications and mortality were compared in 3 groups of patients: patients with normal MPS results, patients with any reversible defect, and patients with a fixed perfusion defect on MPS. In all, 156 subsequent patients underwent OLT. One or more reversible segmental perfusion defects on MPS were present in 14 patients (<3 segments, n = 12; 3 segments without obstructive coronary artery disease, n = 2). The risk of complications did not differ significantly between patients with normal MPS findings and patients with a reversible perfusion defect (odds ratio = 3.04, 95% confidence interval = 0.65-14.26, P = 0.16), although the study was not sufficiently powered to show a difference. The presence of 1 or more reversible defects on MPS was significantly associated with an increased incidence of all-cause 1-year mortality (hazard ratio = 3.17, 95% confidence interval = 1.02-9.83, P = 0.046). No significant difference in the outcomes of patients with normal MPS findings and patients with a fixed defect on MPS was found; the study was, however, not adequately powered to do so. In conclusion, the results of this small cohort study indicate that patients with mild to moderate reversible perfusion defects on MPS may have inferior survival characteristics in comparison with patients with normal MPS results. A prospective, adequately powered study is required to confirm the results of this study. Liver Transpl, 2011. © 2011 AASLD. |
| | |
Authors:
|
Daniela E Oprea-Lager; Bastiaan J Sorgdrager; J Wouter Jukema; Roderick W C Scherptong; Jan Ringers; Minneke J Coenraad; Bart van Hoek; Marcel P M Stokkel |
Related Documents
:
|
6613838 - Side effects and possible contraindications of amiodarone use. 1804288 - Chronic autoimmune thyroid disease. 2823538 - Syndrome of inappropriate antidiuresis in small-cell lung cancer. classification and ef... 15499948 - Contributions of bone maturation measurements to the differential diagnosis of neonatal... 105658 - Enteral hyperalimentation: an alternative to central venous hyperalimentation. 103558 - Serum amyloid a protein in amyloidosis, rheumatic, and enoplastic diseases. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Volume: 17 ISSN: 1527-6473 ISO Abbreviation: Liver Transpl. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100909185 Medline TA: Liver Transpl Country: United States |
Other Details:
|
Languages: eng Pagination: 261-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 American Association for the Study of Liver Diseases. |
Affiliation:
|
Departments of Nuclear Medicine, Leiden University Medical Center, Leiden, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pretransplant depression, antidepressant use, and outcomes of orthotopic liver transplantation.
Next Document: Domino versus deceased donor liver transplantation: Association with early graft function and periop...