Document Detail


Clinical value of immunoscintigraphy in the rectal carcinoma surgery:
MedLine Citation:
PMID:  23340231     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background/Aim: The aim of this study was to evaluate the clinical reliability of the immunoscintigraphy with radiolabeled monoclonal antibodies for the detection of metastases and recurrences of rectal carcinomas. Methodology: A total of 65 patients underwent immunoscintigraphy with radiolabeled monoclonal antibodies. Indication for that examination was suspicious rectal cancer or suspicious rectal cancer recurrence and/or metastases. Results: The method proved to have 92.7% sensitivity, specificity 83.3%, positive predictive value 90.5%, negative predictive value 87.0% and accuracy 89.2%. There was a statistically significant relationship between immunoscintigraphy findings and rectoscopy findings (rs=0.415, p=0.013), as well as significant relationship between immunoscintigraphy findings and US findings (rs=0.332, p=0.001). Tumor marker levels were in positive correlation with findings of immunoscintigraphy (rs=0.845, p=0.001), especially raised CEA level (rs=0.816, p=0.004). Patients with higher CA19-9 level had higher Duke's stage (p=0.025). Conclusions: We can conclude that immunoscintigraphy can be helpful in the detection of metastases and recurrences of colon carcinomas.
Authors:
Milorad Petrovic; Z Jankovic; Lj Jaukovic; Vera Artiko; Dragana Sobic-Saranovic; Andrija Antic; Marinko Zuvela; Nebojsa Radovanovic; Ivan Palibrk; Danijel Galun; Slavko Matic; Zlatibor Loncar; Predrag Bojovic; Boris Ajdinovic; Vladimir Obradovic
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  60     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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