| Clinical value of TSH receptor antibodies measurement in patients with Graves' orbitopathy. | |
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MedLine Citation:
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PMID: 20467363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Graves' orbitopathy (GO) is part of an autoimmune disease, in which TSH-receptor antibodies (TRAb) stimulate the target organs. Most of these patients develop hyperthyroidism and about half an orbitopathy. To ensure the diagnosis, TRAb are determined, especially in patients with GO without associated thyroid disease. Because of their significantly improved sensitivity and equal specificity, second generation TRAb-assays should be preferred. Persisting high TRAb levels are associated with a severe course of GO. TRAb cut off levels are available for prognostic statements during the course of GO and can be applied for crucial treatment decisions. Persisting high TRAb levels are also associated with low remission rates of hyperthyroidism. TRAb cut off levels are available for prognostic statements at 6, 12 and 18 months after the beginning of antithyroid drug treatment. Definitive treatment of the thyroid can be decided early on this basis, which is an advantage for ophthalmosurgical rehabilitation. |
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Authors:
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A Eckstein; J Esser; K Mann; M Schott |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pediatric endocrinology reviews : PER Volume: 7 Suppl 2 ISSN: 1565-4753 ISO Abbreviation: Pediatr Endocrinol Rev Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-06-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101202124 Medline TA: Pediatr Endocrinol Rev Country: Israel |
Other Details:
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Languages: eng Pagination: 198-203 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University Duisburg-Essen, Germany. anja.eckstein@uk-essen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Graves Ophthalmopathy / diagnosis*, immunology* Humans Immunoglobulins, Thyroid-Stimulating / blood* Prognosis Receptors, Thyrotropin / immunology* Recurrence |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Immunoglobulins, Thyroid-Stimulating; 0/Receptors, Thyrotropin; 0/thyrotropin-binding inhibitory immunoglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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