Document Detail

Clinical value of TSH receptor antibodies measurement in patients with Graves' orbitopathy.
MedLine Citation:
PMID:  20467363     Owner:  NLM     Status:  MEDLINE    
Graves' orbitopathy (GO) is part of an autoimmune disease, in which TSH-receptor antibodies (TRAb) stimulate the target organs. Most of these patients develop hyperthyroidism and about half an orbitopathy. To ensure the diagnosis, TRAb are determined, especially in patients with GO without associated thyroid disease. Because of their significantly improved sensitivity and equal specificity, second generation TRAb-assays should be preferred. Persisting high TRAb levels are associated with a severe course of GO. TRAb cut off levels are available for prognostic statements during the course of GO and can be applied for crucial treatment decisions. Persisting high TRAb levels are also associated with low remission rates of hyperthyroidism. TRAb cut off levels are available for prognostic statements at 6, 12 and 18 months after the beginning of antithyroid drug treatment. Definitive treatment of the thyroid can be decided early on this basis, which is an advantage for ophthalmosurgical rehabilitation.
A Eckstein; J Esser; K Mann; M Schott
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric endocrinology reviews : PER     Volume:  7 Suppl 2     ISSN:  1565-4753     ISO Abbreviation:  Pediatr Endocrinol Rev     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101202124     Medline TA:  Pediatr Endocrinol Rev     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  198-203     Citation Subset:  IM    
Department of Ophthalmology, University Duisburg-Essen, Germany.
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MeSH Terms
Biological Markers / blood
Graves Ophthalmopathy / diagnosis*,  immunology*
Immunoglobulins, Thyroid-Stimulating / blood*
Receptors, Thyrotropin / immunology*
Reg. No./Substance:
0/Biological Markers; 0/Immunoglobulins, Thyroid-Stimulating; 0/Receptors, Thyrotropin; 0/thyrotropin-binding inhibitory immunoglobulin

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