Document Detail

Clinical value of 99mTc-HMPAO SPECT in depressed bipolar I patients.
MedLine Citation:
PMID:  15664800     Owner:  NLM     Status:  MEDLINE    
Regional cerebral blood flow was studied in 17 bipolar I depressed patients (DSM-IV criteria) with single photon emission computed tomography (SPECT). Visual analysis of images revealed no abnormality in eight patients and abnormal findings in nine patients. In the nine patients with abnormal findings, all showed regional decreases of the uptake of (99m)Tc-D,L-hexamethylpropylene amine oxime (HMPAO, four in the frontal region, two in the basal ganglia, and three in both the frontal region and the basal ganglia). The patients with visible SPECT abnormalities had significantly higher scores on the Hamilton Rating Scale for Depression (HDRS).
Antoni Benabarre; Eduard Vieta; Francisco Martín; Francisco Lomeña; Anabel Martínez-Aràn; Francesc Colom; Barbara Corbella; Cristóbal Gastó; Manuel Valdés
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  132     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-24     Completed Date:  2005-03-31     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  285-9     Citation Subset:  IM    
Institut Clínic de Psiquiatria i Psicologia, Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, C/Villarroel 170, 08036 Barcelona, Spain.
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MeSH Terms
Basal Ganglia / blood supply
Bipolar Disorder / diagnosis*
Brain / blood supply*
Diagnostic and Statistical Manual of Mental Disorders
Frontal Lobe / blood supply
Middle Aged
Radiopharmaceuticals / diagnostic use*
Regional Blood Flow
Technetium Tc 99m Exametazime / diagnostic use*
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime

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