Document Detail


Clinical utility of telangiectasia of hands in scleroderma and other rheumatic disorders.
MedLine Citation:
PMID:  12125921     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Telangiectasia of the hands were observed in 76% of patients with scleroderma (n = 53) as compared with 12% of patients with other rheumatic disorders (n = 100) and in 13% of healthy subjects (n = 30). In scleroderma, telangiectasia of the hands were commonly multiple (mean number +/- SD = 22.9+/-30.1) with 7.3% being >1 mm in size. They were found in greater numbers in those patients with the limited subtype. The distribution of telangiectasia was observed on all but 4 of 158 sectors of the hand with significant higher numbers on the ventral surface of the digits. Significant associations of telangiectasia of the hands were also observed with numbers of telangiectasia on face and lips (p = 0.001), disease duration (p = 0.002), surface area of digital calcinosis (p = 0.03) and with the presence of the centromere antibody (p = 0.005). Possible associations were observed with prior gastrointestinal bleeds (particularly with telangiectasia >1 mm) and with isolated pulmonary hypertension. No significant correlation was found between number of telangiectasia and with nailfold capillary size or density. In conclusion, multiple telangiectasia of the hands were most commonly observed in patients with the centromere positive, limited subtype of scleroderma of long duration. Their pathogenesis is unknown.
Authors:
Peter J Robert-Thomson; Tiffany L Mould; Jennifer G Walker; Malcolm D Smith; Michael J Ahern
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand     Volume:  20     ISSN:  0125-877X     ISO Abbreviation:  Asian Pac. J. Allergy Immunol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-07-19     Completed Date:  2003-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402034     Medline TA:  Asian Pac J Allergy Immunol     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
Affiliation:
Department of Immunology, Allergy & Arthritis, Flinders Medical Centre, Bedford Park, South Australia.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple
Adult
Aged
Aged, 80 and over
Capillaries / pathology
Female
Gastrointestinal Hemorrhage / complications
Hand / blood supply*,  pathology
Hand Dermatoses / complications*
Humans
Male
Middle Aged
Rheumatic Diseases / complications*
Scleroderma, Systemic / complications*
Telangiectasis / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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