Document Detail

Clinical utility of serum cystatin C in predicting coronary artery disease.
MedLine Citation:
PMID:  20690093     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is limited data regarding the clinical utility of cystatin C in patients with stable coronary artery disease (CAD). The aim of this study was to determine the predictive value of cystatin C for the presence and severity of CAD and the association between this protein and other biochemical risk factors for atherosclerosis in patients with suspected CAD.
METHODS: Ninety-four patients with CAD, and 92 patients without CAD but with cardiovascular risk factors, were included in this study. Echocardiography and other pertinent laboratory examinations were performed. Subjects were divided into four groups according to their cystatin C quartile. Cystatin C groups were analyzed for the association with CAD characteristics.
RESULTS: The number of patients with CAD increased as the quartile of cystatin C increased, and there was a remarkable difference between quartiles (p < 0.001). Logistic regression analysis revealed independent predictors of incident CAD as cystatin C, hs-CRP, eGFR, HDL cholesterol and SBP (p = 0.005, p = 0.027, p = 0.017, p = 0.014 and p = 0.001, respectively). Moreover, cystatin C concentration was significantly correlated with CAD severity score (b = 0.258, p < 0.01). A cut-off value of 0.82 mg/L for cystatin C predicted incident CAD with a sensitivity and specificity of 75.5% and 75.0% respectively. Cystatin C concentration also correlated well with the atherosclerotic biochemical risk factors like homocysteine, creatinine and hs-CRP.
CONCLUSIONS: Cystatin C could be a useful laboratory tool in predicting the presence and severity of CAD in daily practice. It also correlates significantly with biochemical risk factors for CAD, namely homocysteine, low HDL and CRP.
Mevlut Koc; Mustafa Kemal Batur; Osman Karaarslan; Gülcan Abali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-06     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  374-80     Citation Subset:  IM    
Adana Numune Education and Research Hospital, Department of Cardiology, Adana, Turkey.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / analysis
Chi-Square Distribution
Cholesterol, HDL / blood
Coronary Angiography
Coronary Stenosis / blood,  diagnosis*,  radiography,  ultrasonography
Cross-Sectional Studies
Cystatin C / blood*
Homocysteine / blood
Linear Models
Logistic Models
Middle Aged
Predictive Value of Tests
Risk Assessment
Risk Factors
Severity of Illness Index
Reg. No./Substance:
0/Biological Markers; 0/CST3 protein, human; 0/Cholesterol, HDL; 0/Cystatin C; 454-28-4/Homocysteine; 9007-41-4/C-Reactive Protein

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