Document Detail

Clinical utility and prognostic value of bronchoalveolar lavage galactomannan in patients with hematologic malignancies.
MedLine Citation:
PMID:  20846585     Owner:  NLM     Status:  MEDLINE    
We conducted a single-center retrospective cohort study to determine the performance characteristics of the galactomannan (GM) assay in bronchoalveolar lavage (BAL) in patients with hematologic malignancies. Patients were classified as proven, probable, possible, or no invasive pulmonary aspergillosis (IPA), according to international guidelines. A total of 173 BAL samples from 145 patients were included. There were 5 proven, 7 probable, and 35 possible cases of IPA. Using a GM index cutoff of ≥ 0.5, the sensitivity, specificity, and positive and negative predictive values (PPV and NPV, respectively) of the BAL GM assay were 100%, 78%, 26%, and 100%, respectively. Using a GM index cutoff of ≥ 2.0, the sensitivity and NPV remained 100%, but specificity and PPV increased to 93% and 50%, respectively. The BAL GM assay is a highly sensitive screening test for IPA in patients with hematologic malignancies. Increasing the cutoff value to 2.0 would improve the performance of this assay.
Me-Linh Luong; Charles Filion; Annie-Claude Labbé; Jean Roy; Jacques Pépin; Julia Cadrin-Tourigny; Stéphane Carignan; Donald C Sheppard; Michel Laverdière
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  68     ISSN:  1879-0070     ISO Abbreviation:  Diagn. Microbiol. Infect. Dis.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-17     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Microbiology, McGill University Health Center, Montreal, Quebec, Canada.
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MeSH Terms
Antigens, Fungal / analysis
Aspergillus / immunology,  isolation & purification*
Bronchoalveolar Lavage
Bronchoalveolar Lavage Fluid / chemistry*
Cohort Studies
Hematologic Neoplasms / complications*
Hematopoietic Stem Cell Transplantation
Immunoenzyme Techniques
Invasive Pulmonary Aspergillosis / diagnosis*,  microbiology
Mannans / analysis*,  immunology
Middle Aged
Mycological Typing Techniques
Opportunistic Infections / diagnosis,  microbiology
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity
Reg. No./Substance:
0/Antigens, Fungal; 0/Mannans; 11078-30-1/galactomannan

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