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Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury.
MedLine Citation:
PMID:  24184304     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: to test the clinical utility of an early amplitude-integrated electroencephalography (aEEG) to predict short-term neurological outcome in term newborns at risk of neurology injury.
METHODS: this was a prospective, descriptive study. The inclusion criteria were neonatal encephalopathy, neurologic disturbances, and severe respiratory distress syndrome. Sensitivity, specificity, positive and negative predictive values, and likelihood ratio (LR) were calculated. Clinical and demographic data were analyzed. Neurological outcome was defined as the sum of clinical, electroimaging, and neuroimaging findings.
RESULTS: ten of the 21 monitored infants (48%) presented altered short-term neurologic outcome. The aEEG had 90% sensitivity, 82% specificity, 82% positive predictive value, and 90% negative predictive value. The positive LR was 4.95, and the negative LR was 0.12. In three of 12 (25%) encephalopathic infants, the aEEG allowed for a better definition of the severity of their condition. Seizures were detected in eight infants (38%), all subclinical at baseline, and none had a normal aEEG background pattern. The status of three infants (43%) evolved and required two or more drugs for treatment.
CONCLUSIONS: in infants with encephalopathy or other severe illness, aEEG disturbances occur frequently. aEEG provided a better classification of the severity of encephalopathy, detected early subclinical seizures, and allowed for monitoring of the response to treatment. aEEG was a useful tool at the neonatal intensive care unit for predicting poor short-term neurological outcomes for all sick newborn.
Authors:
Paulina A Toso; Alvaro J González; María E Pérez; Javier Kattan; Jorge G Fabres; José L Tapia; Hernán S González
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-29
Journal Detail:
Title:  Jornal de pediatria     Volume:  -     ISSN:  1678-4782     ISO Abbreviation:  J Pediatr (Rio J)     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-11-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985188R     Medline TA:  J Pediatr (Rio J)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
Affiliation:
Division of Pediatrics, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: ptoso@med.puc.cl.
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