Document Detail

Clinical utility of biomarkers in premature atherosclerosis.
MedLine Citation:
PMID:  22489712     Owner:  NLM     Status:  Publisher    
Atherosclerosis is a very complex procedure responsible for the development of coronary artery disease which is the leading cause of death in the civilized world. The obvious pandemic character of atherosclerosis augments the need to discover an ideal biomarker, which will be able to facilitate the clinical diagnosis of the atherosclerosis from the physicians especially in the early stages of the atherosclerotic process. Among the biomarkers that are already used there are classical ones, such as c-reactive protein, interleukins, tumour necrosis factor, apolipoproteins, fibrinogen, homocysteine, and novel promising ones such as lipoprotein-associated phospholipase, asymmetric dimethylarginine, myeloperoxidase, cathepsins and cystatin C. The possibility of combining circulating biomarkers with other methods such as non-invasive and invasive imaging is clinically attractive because this could contribute to improved diagnosis and understanding of premature atherosclerosis pathogenesis.
Anna-Maria Kampoli; Dimitris Tousoulis; Nikolaos Papageorgiou; Zoi Pallatza; Georgia Vogiatzi; Alexandros Briasoulis; Emmanouel Androulakis; Costas Toutouzas; Pavlos Stougianos; Costas Tentolouris; Christodoulos Stefanadis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-6
Journal Detail:
Title:  Current medicinal chemistry     Volume:  -     ISSN:  1875-533X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1st Cardiology Unit, Hippokration Hospital Athens University Medical School Athens, Greece.
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