| Clinical utility of 18F FDG-PET/CT in the detection of bone marrow disease in Hodgkin's lymphoma. | |
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MedLine Citation:
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PMID: 22215887 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: The aim of the study is to evaluate the potential role of fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT in the detection of bone/bone marrow disease in patients with Hodgkin's Lymphoma (HL).Methods: We retrospectively reviewedfluorine-18 ((18)F)-FDG-PET/CT scans of 122 newly diagnosed, biopsy proven cases of HL performed between November 2009 and June 2010. All the patients were staged before treatment by both PET/CT and bone marrow biopsy (BMB). Patients were sub-divided into three groups based on the findings of FDG-PET/CT. Group A consisted of patients showing diffuse FDG uptake, Group B consisted of patients showing unifocal FDG uptake and Group C patients showed multifocal FDG-avid foci on PET/CT scans. Bone marrow results were also reviewed and considered positive if lymphomatous involvement was detected on bone marrow trephine biopsy. BMB results were correlated with FDG-PET/CT findings.Results: There were 122 patients in total-81 (66.4%) were male and 41 (33.6%) were female. The age range was from 6 years to 78 years (mean 35.70 years). PET/CT was reported as negative for bone/bone marrow involvement in 85 (69.7%) patients, while the remaining 37 showed abnormal FDG uptake. The sensitivity of FDG-PET/CT was calculated to be 100%, the specificity was 76.57%, the negative predictive value was 76.57%, the positive predictive value was 29.72% and the diagnostic accuracy was 78.62%.Conclusion: (18)F-FDG-PET/CT and BMB are complementary in the evaluation of bone marrow disease. |
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Authors:
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S Muzahir; M Mian; I Munir; M Khalid Nawaz; Z Salman Faruqui; K Aftab Mufti; H Bashir; N Uddin; N Siddiqui; A Ur Rehman Maaz; M Tariq Mahmood |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-3 |
Journal Detail:
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Title: The British journal of radiology Volume: - ISSN: 1748-880X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Pakistan. |
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