| Clinical usefulness of tissue Doppler imaging in patients with mild to moderate aortic stenosis: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin study. | |
| | |
MedLine Citation:
|
PMID: 18406575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Although impaired diastolic function is common in aortic stenosis (AS), little is known about the clinical usefulness of tissue Doppler imaging (TDI) to detect diastolic dysfunction in patients with mild to moderate AS. The objective was to describe both conventional and TDI measurements of diastolic function in asymptomatic patients enrolled in the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin study, a multicenter study to assess the effect of rosuvastatin on the progression of AS. METHODS: Baseline echocardiography measurements, including left ventricular interventricular septal thickness, posterior wall thickness, cavity dimensions, and ejection fraction were obtained. Conventional Doppler indices, including peak early (E) and late (A) transmitral velocities, E/A ratio, and E-wave deceleration time, were measured from spectral Doppler. Tissue Doppler measurements, including early (E') and late (A') velocities of the lateral annulus, were determined, and E/E' was calculated. RESULTS: The study population included 172 patients (aged 57 +/- 13 years; 73 were female) divided into three categories of AS severity on the basis of peak velocity at baseline (group I: 2.5-3.0 m/s; group II: 3.1-3.5 m/s; group III; 3.6-4.0 m/s). Baseline hemodynamics, left ventricular dimensions, and conventional diastolic functional parameters were similar among all 3 groups. In patients with greater severity of AS, the lateral E' was lower and the E/E' (as an estimate of increased left ventricular end-diastolic pressure) was higher (P <.05). CONCLUSION: In patients with mild to moderate asymptomatic AS, TDI measures of diastolic function are abnormal and related to the severity of AS. These findings may help to predict the future development of symptoms in this population. |
| | |
Authors:
|
Davinder S Jassal; James W Tam; Jean G Dumesnil; Peter J Giannoccaro; John Jue; A Shekhar Pandey; Campbell D Joyner; Koon K Teo; Kwan L Chan |
Related Documents
:
|
12511535 - Hepatocyte growth factor and left ventricular geometry in end-stage renal disease. 14617545 - Interventricular and intra-left ventricular electromechanical delays in right ventricul... 9388095 - Comparison of left ventricular function and volumes during transesophageal atrial pacin... 8610415 - Two-dimensional and dobutamine stress echocardiography in the preoperative assessment o... 1636515 - Spinal mr findings in neurofibromatosis types 1 and 2. 267465 - Acute pancreatitis: the queensland scene. |
Publication Detail:
|
Type: Clinical Trial; Journal Article Date: 2008-04-11 |
Journal Detail:
|
Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 21 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-09-03 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
|
Languages: eng Pagination: 1023-7 Citation Subset: IM |
Affiliation:
|
Cardiology Division, Department of Cardiac Sciences, St. Boniface General Hospital, Winnipeg, Manitoba, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Aortic Valve Stenosis / complications, drug therapy*, ultrasonography* Echocardiography, Doppler / methods* Female Fluorobenzenes / therapeutic use* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Male Middle Aged Prognosis Pyrimidines / therapeutic use* Reproducibility of Results Sensitivity and Specificity Sulfonamides / therapeutic use* Treatment Outcome Ventricular Dysfunction, Left / etiology, prevention & control*, ultrasonography* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Fluorobenzenes; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Sulfonamides; 287714-41-4/rosuvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness.
Next Document: CD127 immunophenotyping suggests altered CD4+ T cell regulation in primary progressive multiple scle...