Document Detail

Clinical usefulness of serum pepsinogens I and II, gastrin-17 and anti-Helicobacterpylori antibodies in the management of dyspeptic patients in primary care.
MedLine Citation:
PMID:  15975537     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several tests have been proposed for evaluating dyspeptic symptoms and their relationship to the underlying gastric disease. Serum pepsinogens and gastrin-17 are known to be useful biomarkers for the detection of gastric pathologies. AIM: To evaluate the capability of screening dyspeptic patients in the primary care by analyses of serum pepsinogens I (sPGI) and II (sPGII), gastrin-17 (sG-17) and the IgG anti-Helicobacter pylori antibodies (IgG-Hp). PATIENTS AND METHODS: Three hundred and sixty-two consecutive patients with dyspeptic symptoms (208 females, mean age 50.6 +/- 16 years, range 18-88 years) referred by general practitioners for upper gastrointestinal endoscopy were enrolled. A blood sample was taken from each subject for IgG-Hp, sPGI, sPGII and sG-17 analyses. RESULTS: Two hundred and eighty-seven patients had a complete screening; of these, 132 resulted positive for Hp infection. Patients with atrophic chronic gastritis showed significantly lower serum pepsinogen I levels and sPGI/sPGII ratio than patients with non-atrophic chronic gastritis. Moreover, by calculating the values of sPGI by sG-17 and sG-17 by sPGII/sPGI, subjects with atrophic chronic gastritis could be distinguished from those with non-atrophic chronic gastritis and from those with normal mucosa, respectively. sG-17 levels were found to be a useful biomarker for the detection of antral atrophic gastritis, while the combination of sPGI, the sPGI/sPGII ratio and sG-17 was found effective in identifying corpus atrophy. CONCLUSION: A panel composed of PGI, PGII, G-17 and IgG-Hp could be used as a first approach in the 'test and scope' and/or 'test and treat' strategy in the primary care management of dyspeptic patients.
B Germaná; F Di Mario; L G Cavallaro; A M Moussa; P Lecis; S Liatoupolou; G Comparato; C Carloni; G Bertiato; M Battiestel; N Papa; G Aragona; G M Cavestro; V Iori; R Merli; S Bertolini; P Caruana; A Franzé
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2005-04-18
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  37     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2005-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  501-8     Citation Subset:  IM    
Gastroenterology Unit, S. Martino Hospital, Belluno, Italy.
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MeSH Terms
Aged, 80 and over
Antibodies, Bacterial / analysis*
Chronic Disease
Dyspepsia / blood*,  etiology
Gastrins / blood*
Gastritis / complications,  diagnosis*,  microbiology
Helicobacter pylori / immunology*
Immunoglobulin G / immunology
Mass Screening
Middle Aged
Pepsinogen A / blood*
Pepsinogen C / blood*
Primary Health Care
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Gastrins; 0/Immunoglobulin G; 60748-06-3/gastrin 17; 61536-72-9/Pepsinogen C; 9001-10-9/Pepsinogen A

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