| Clinical usefulness of serum pepsinogens I and II, gastrin-17 and anti-Helicobacterpylori antibodies in the management of dyspeptic patients in primary care. | |
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MedLine Citation:
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PMID: 15975537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Several tests have been proposed for evaluating dyspeptic symptoms and their relationship to the underlying gastric disease. Serum pepsinogens and gastrin-17 are known to be useful biomarkers for the detection of gastric pathologies. AIM: To evaluate the capability of screening dyspeptic patients in the primary care by analyses of serum pepsinogens I (sPGI) and II (sPGII), gastrin-17 (sG-17) and the IgG anti-Helicobacter pylori antibodies (IgG-Hp). PATIENTS AND METHODS: Three hundred and sixty-two consecutive patients with dyspeptic symptoms (208 females, mean age 50.6 +/- 16 years, range 18-88 years) referred by general practitioners for upper gastrointestinal endoscopy were enrolled. A blood sample was taken from each subject for IgG-Hp, sPGI, sPGII and sG-17 analyses. RESULTS: Two hundred and eighty-seven patients had a complete screening; of these, 132 resulted positive for Hp infection. Patients with atrophic chronic gastritis showed significantly lower serum pepsinogen I levels and sPGI/sPGII ratio than patients with non-atrophic chronic gastritis. Moreover, by calculating the values of sPGI by sG-17 and sG-17 by sPGII/sPGI, subjects with atrophic chronic gastritis could be distinguished from those with non-atrophic chronic gastritis and from those with normal mucosa, respectively. sG-17 levels were found to be a useful biomarker for the detection of antral atrophic gastritis, while the combination of sPGI, the sPGI/sPGII ratio and sG-17 was found effective in identifying corpus atrophy. CONCLUSION: A panel composed of PGI, PGII, G-17 and IgG-Hp could be used as a first approach in the 'test and scope' and/or 'test and treat' strategy in the primary care management of dyspeptic patients. |
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Authors:
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B Germaná; F Di Mario; L G Cavallaro; A M Moussa; P Lecis; S Liatoupolou; G Comparato; C Carloni; G Bertiato; M Battiestel; N Papa; G Aragona; G M Cavestro; V Iori; R Merli; S Bertolini; P Caruana; A Franzé |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2005-04-18 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 37 ISSN: 1590-8658 ISO Abbreviation: Dig Liver Dis Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-24 Completed Date: 2005-10-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 501-8 Citation Subset: IM |
Affiliation:
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Gastroenterology Unit, S. Martino Hospital, Belluno, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antibodies, Bacterial / analysis* Chronic Disease Dyspepsia / blood*, etiology Female Gastrins / blood* Gastritis / complications, diagnosis*, microbiology Gastroscopy Helicobacter pylori / immunology* Humans Immunoglobulin G / immunology Male Mass Screening Middle Aged Pepsinogen A / blood* Pepsinogen C / blood* Primary Health Care |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Gastrins; 0/Immunoglobulin G; 60748-06-3/gastrin 17; 61536-72-9/Pepsinogen C; 9001-10-9/Pepsinogen A |
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