| Clinical usefulness of per-rectal portal scintigraphy by Tc-99m pertechnetate in evaluation of the severity of portal hypertension in cirrhotic patients. | |
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MedLine Citation:
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PMID: 18043841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Variceal haemorrhage is a potentially life-threatening complication in cirrhotic patients. Identification of patients at high risk for bleeding is particularly important. The aim of this study was to determine the clinical usefulness of per-rectal portal scintigraphy (PPS) in the evaluation of the severity of portal hypertension in cirrhotic patients, in terms of correlation between cirrhosis and the parameters of hepatic functional reserve, and identifying the difference of the portal shunt index (PSI) of the bleeding oesophageal variceal (BEV) patients and non-BEV patients. METHODS: Portal circulations in 67 patients with cirrhosis and oesophageal varices were evaluated by Tc-99m pertechnetate PPS. Tc-99m pertechnetate (550 MBq) was instilled into the upper rectum, and dynamic images of upper abdomen were taken. Radioactivity curves for the liver and the heart were generated sequentially. Through the analysis of these curves, the PSI was determined. RESULTS: The results, expressed as PSI, were: 11.4 +/- 98.4 percent (mean 66.8) in all 67 cirrhotic patients, 56.4 +/- 27.1 percent in cirrhotic patients without history of BEV, and 74.9 +/- 13.6 percent in cirrhotic patients with history of BEV. The PSI was significantly lower in cirrhotic patients without BEV than those with BEV (p-value equals 0.001). The PSI calculated with this method was correlated with the serum albumin, the serum bilirubin, the prothrombin time, and the Child-Turcotte-Pugh score. CONCLUSION: Tc-99m pertechnetate PPS has clinical usefulness as a noninvasive method of choice for quantitatively evaluating the severity of portal hypertension in cirrhotic patients. |
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Authors:
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S Namwongprom; M Ekmahachai; N Vilasdechanon; N Chankaew; S Boonyaprapa; T Chitapanarux |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Singapore medical journal Volume: 48 ISSN: 0037-5675 ISO Abbreviation: Singapore Med J Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-28 Completed Date: 2008-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404516 Medline TA: Singapore Med J Country: Singapore |
Other Details:
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Languages: eng Pagination: 1125-30 Citation Subset: IM |
Affiliation:
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Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. snamwong@mail.med.cmu.ac.th |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Rectal Adult Cohort Studies Female Humans Hypertension, Portal / physiopathology, radionuclide imaging*, surgery Liver Cirrhosis / physiopathology, radionuclide imaging*, surgery Liver Function Tests Male Middle Aged Portasystemic Shunt, Surgical / methods Probability Radiopharmaceuticals / diagnostic use Risk Assessment Sensitivity and Specificity Severity of Illness Index Sodium Pertechnetate Tc 99m / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 23288-60-0/Sodium Pertechnetate Tc 99m |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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