| Clinical usefulness of microsatellite instability test in Korean young patients with high-risk features associated with adenoma. | |
| | |
MedLine Citation:
|
PMID: 22361441 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of this study was to determine the correlation between microsatellite instability (MSI) and young age in patients with advanced colorectal adenomas. We retrospectively analyzed young patients (≤40years of age) with advanced adenomas (n=84) between January 1996 and December 2006. We randomly selected the control group as patients≥50years of age with advanced adenomas (n=84) during the same time period. Of these patients, the MSI test and MLH1 immunohistochemistry were performed in the available tissue samples from patients with advanced adenomas. The number of patients who had the two tests was 52 in the young group and 49 in the old group. The monomorphic nature of the BAT26 panel for MSI analysis was used without comparison of normal tissue. MSI was detected in three young patients (n=52) and none of the old patients (n=49). There was no statistical difference between the two groups (P=0.243). All three young patients with MSI had a strong family history of colorectal cancer. MSI analysis was not a useful method of screening for HNPCC in young patients with advanced colorectal adenoma, at least in cases without a family history of colorectal cancer. |
| | |
Authors:
|
Ki Joo Kang; Byung-Hoon Min; Kyungju Ryu; Kyoung-Mee Kim; Eun Ran Kim; Jin Yong Kim; Dong Kyung Chang; Jae J Kim; Jong Chul Rhee; Young-Ho Kim |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-21 |
Journal Detail:
|
Title: Clinics and research in hepatology and gastroenterology Volume: - ISSN: 2210-741X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101553659 Medline TA: Clin Res Hepatol Gastroenterol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Masson SAS. |
Affiliation:
|
Department of Medicine, Samsung Medical Center, Division of Gastroenterology, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute pancreatitis associated with H1N1 influenza during 2009 pandemic: A case report.
Next Document: Radiofrequency ablation associated to mucosal resection in the oesophagus: Experience in a single ce...