| Clinical usefulness of B-type natriuretic peptide in the diagnosis of pleural effusions due to heart failure. | |
| | |
MedLine Citation:
|
PMID: 21261781 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
SUMMARY AT A GLANCE: Plasma and pleural fluid B-type natriuretic peptide concentrations were determined in 77 patients with pleural effusions and were shown to be useful in identifying effusions with a cardiac aetiology. ABSTRACT: Background and objective: Light's criteria are frequently used to evaluate the exudative or transudative nature of pleural effusions. However, misclassification resulting from the use of Light's criteria has been reported, especially in the setting of diuretic use in patients with heart failure (HF). The objective of this study was to evaluate the utility of B-type natriuretic peptide (BNP) measurements as a diagnostic tool for determining the cardiac aetiology of pleural effusions. Methods: Patients with pleural effusions attributable to HF (n= 34), hepatic hydrothorax (n= 10), pleural effusions due to cancer (n= 21), and pleural effusions due to tuberculosis (n= 12) were studied. Diagnostic thoracentesis was performed for all 77 patients. Receiver operating characteristic (ROC) curves were constructed to determine the diagnostic accuracy of plasma BNP and pleural fluid BNP for the prediction of HF. Results: The areas under the ROC curves were 0.987 (95% CI 0.93 - 0.998) for plasma BNP and 0.949 (95% CI 0.874 - 0.986) for pleural fluid BNP, for distinguishing between patients with pleural effusions caused by HF (n= 34) and those with pleural effusions attributable to other causes (n= 43). The cut-off concentrations with the highest diagnostic accuracy for the diagnosis of HF as the cause of pleural effusion were 132 pg/mL for plasma BNP (sensitivity 97.1%, specificity 97.4%) and 127 pg/mL for pleural fluid BNP (sensitivity 97.1%, specificity 87.8%). Conclusions: In patients with pleural effusions of suspected cardiac origin, measurements of BNP in plasma and pleural fluid may be useful for the diagnosis of HF as the underlying cause. |
| | |
Authors:
|
Felipe C A Marinho; Francisco S Vargas; José Fabri; Milena M P Acencio; Eduardo H Genofre; Leila Antonangelo; Roberta K B Sales; Lisete R Teixeira |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-25 |
Journal Detail:
|
Title: Respirology (Carlton, Vic.) Volume: - ISSN: 1440-1843 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9616368 Medline TA: Respirology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology. |
Affiliation:
|
Pulmonary Division and Emergency Service, Pleura Laboratory, Heart Institute (InCor), University of São Paulo Medical School, Sao Paulo, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regional ventilation distribution determined by electrical impedance tomography: reproducibility and...
Next Document: Sputum zinc concentration and clinical outcome in older asthmatics.